{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"infections::TDM_ANTIBIOTICS_PM","issue_slug":"infections","doc_id":"TDM_ANTIBIOTICS_PM","title":"Therapeutic Drug Monitoring (TDM) of Antibiotics","doi":"10.62487/saimsara002717c5","doi_url":"https://doi.org/10.62487/saimsara002717c5","version":"2026-05-13","source_name":"PubMed","article_url":"https://saimsara.com/sessions/therapeutic-drug-monitoring-antibiotics-20260513-170910-002717c5/","image_url":"","topic_tags":"Therapeutic drug monitoring,Antibiotics,Pharmacokinetics,Pharmacodynamics,Dose optimization,Critically ill patients,Beta-lactams,Vancomycin,Aminoglycosides,Sepsis","keywords":["Therapeutic drug monitoring","Antibiotics","Pharmacokinetics","Pharmacodynamics","Dose optimization","Critically ill patients","Beta-lactams","Vancomycin","Aminoglycosides","Sepsis"],"metrics":{"included_all":508,"included_original":394,"reference_index":175,"total_participants":430680},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=infections%3A%3ATDM_ANTIBIOTICS_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=infections%3A%3ATDM_ANTIBIOTICS_PM","price":{"amount":"9.00","currency":"USD","units":9,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":23302,"preview":"Results Key finding aligned to the query: The central scoping-review finding is that antibiotic TDM most consistently functions as a practical precision-dosing tool for identifying underexposure, overexposure, and dose-adjustment needs in settings where antibiotic pharmacokinetics are unstable or poorly predicted by standard dosing. This signal recurred across β-lactams, vancomycin, aminoglycosides, linezolid, teicoplanin, polymyxins, and newer anti-infectives, especially in critically ill patients, pediatric and neonatal patients, burn patients, cystic fibrosis populations, patients with renal dysfunction or augmented renal clearance, and patients receiving ECMO or renal replacement therapy…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"infections::TDM_ANTIBIOTICS_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"9.00","currency":"USD","units":9,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=infections::TDM_ANTIBIOTICS_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=infections%3A%3ATDM_ANTIBIOTICS_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=infections%3A%3ATDM_ANTIBIOTICS_PM\""}}}