{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"longevity::PROLONGED_FASTING_PM","issue_slug":"longevity","doc_id":"PROLONGED_FASTING_PM","title":"Prolonged Fasting","doi":"10.62487/saimsara93074bf6","doi_url":"https://doi.org/10.62487/saimsara93074bf6","version":"2026-03-21","source_name":"PubMed","article_url":"https://saimsara.com/sessions/prolonged-fasting-20260222-221118-93074bf6/","image_url":"","topic_tags":"Metabolic adaptation,Glycemic control,Insulin sensitivity,Stem cell regeneration,Gut microbiome,Proteomic changes,Lipid metabolism,Brain function,Cancer therapy,Aging physiology","keywords":["Metabolic adaptation","Glycemic control","Insulin sensitivity","Stem cell regeneration","Gut microbiome","Proteomic changes","Lipid metabolism","Brain function","Cancer therapy","Aging physiology"],"metrics":{"included_all":1513,"included_original":1402,"reference_index":95,"total_participants":378628},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=longevity%3A%3APROLONGED_FASTING_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=longevity%3A%3APROLONGED_FASTING_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":10355,"preview":"Results Key finding aligned to the query: Prolonged fasting induces profound, multi-organ systemic adaptations, characterized by significant proteomic and lipidomic remodeling, epigenetic changes, and altered cellular signaling pathways that collectively promote metabolic flexibility and cellular regeneration. For instance, a 7-day water-only fast in healthy volunteers induced systemic proteomic changes in over 1,000 proteins, while a 36-hour fast significantly remodeled the plasma lipidome. These adaptations include reduced IGF-1/PKA signaling to promote hematopoietic stem cell regeneration in mice and improved glucose tolerance and insulin release in humans. Original research topic synthes…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"longevity::PROLONGED_FASTING_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=longevity::PROLONGED_FASTING_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=longevity%3A%3APROLONGED_FASTING_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=longevity%3A%3APROLONGED_FASTING_PM\""}}}