{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"longevity::Y_CHROMOSOME_LOSS_SS","issue_slug":"longevity","doc_id":"Y_CHROMOSOME_LOSS_SS","title":"Y Chromosome Loss","doi":"10.62487/saimsaraab15307b","doi_url":"https://doi.org/10.62487/saimsaraab15307b","version":"2026-02-28","source_name":"Europe PMC","article_url":"https://saimsara.com/sessions/chromosome-loss-20260222-084715-ab15307b/","image_url":"","topic_tags":"Loss of Y chromosome,Mosaic LOY,Cancer,Tumor progression,Alzheimer's disease,Clonal hematopoiesis,Cardiovascular disease,Myocardial infarction,Amyotrophic lateral sclerosis","keywords":["Loss of Y chromosome","Mosaic LOY","Cancer","Tumor progression","Alzheimer's disease","Clonal hematopoiesis","Cardiovascular disease","Myocardial infarction","Amyotrophic lateral sclerosis"],"metrics":{"included_all":1422,"included_original":1048,"reference_index":95,"total_participants":5855590},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=longevity%3A%3AY_CHROMOSOME_LOSS_SS","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=longevity%3A%3AY_CHROMOSOME_LOSS_SS","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":7169,"preview":"Results Main numerical result aligned to the query: Loss of Y chromosome (LOY) is significantly associated with increased morbidity and mortality across multiple disease categories in men. Specifically, substantial LOY (decile 10) is associated with a 68% higher risk of myocardial infarction (MI) in older men (HR: 1.68; 95% CI: 1.16-2.54). Furthermore, LOY > 17% is linked to a 41% higher all-cause mortality risk (HR 1.41, 95% CI 1.09-1.82) and 49% higher cardiovascular mortality risk (HR 1.49, 95% CI 1.09-2.03) in male patients with coronary artery disease, with a 2.65-fold higher risk for fatal MI (HR 2.65, 95% CI 1.46-4.81). In male STEMI patients, LOY ≥ 18% increased mortality risk to 2.4…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"longevity::Y_CHROMOSOME_LOSS_SS"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=longevity::Y_CHROMOSOME_LOSS_SS\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=longevity%3A%3AY_CHROMOSOME_LOSS_SS","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=longevity%3A%3AY_CHROMOSOME_LOSS_SS\""}}}