{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"mental::NEUROLEPTIC_SIDE_EFFECTS_PM","issue_slug":"mental","doc_id":"NEUROLEPTIC_SIDE_EFFECTS_PM","title":"Antipsychotic and Neuroleptic Side Effects","doi":"10.62487/saimsara690dd0a7","doi_url":"https://doi.org/10.62487/saimsara690dd0a7","version":"2026-05-17","source_name":"PubMed","article_url":"https://saimsara.com/sessions/side-effects-neuroleptics-20260516-233742-690dd0a7/","image_url":"https://youtu.be/QFKj6zfPwIY","topic_tags":"Neuroleptic adverse effects,Extrapyramidal symptoms,Tardive dyskinesia,Drug-induced parkinsonism,Akathisia,Hyperprolactinemia,Antipsychotic polypharmacy,Weight gain,Clozapine tolerability,Dopamine D2 receptors","keywords":["Neuroleptic adverse effects","Extrapyramidal symptoms","Tardive dyskinesia","Drug-induced parkinsonism","Akathisia","Hyperprolactinemia","Antipsychotic polypharmacy","Weight gain","Clozapine tolerability","Dopamine D2 receptors"],"metrics":{"included_all":699,"included_original":514,"reference_index":140,"total_participants":419769},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=mental%3A%3ANEUROLEPTIC_SIDE_EFFECTS_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3ANEUROLEPTIC_SIDE_EFFECTS_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":30127,"preview":"Results Key finding aligned to the query: The most consistent paper-level finding is that neuroleptic side effects are dominated by extrapyramidal side effects (EPS)—including parkinsonism, akathisia, dystonia, dyskinesia, and tardive dyskinesia—while newer or atypical agents often reduce, but do not eliminate, this motor burden and may shift toxicity toward metabolic, autonomic, endocrine, and sedative effects. Representative studies reported dyskinesia in 44% of elderly neuroleptic-treated psychiatric inpatients versus 14% of non-treated patients, a 26% one-year cumulative incidence of tardive dyskinesia in older schizophrenia patients, 62% acute akathisia within two weeks among psychotic…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"mental::NEUROLEPTIC_SIDE_EFFECTS_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=mental::NEUROLEPTIC_SIDE_EFFECTS_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3ANEUROLEPTIC_SIDE_EFFECTS_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3ANEUROLEPTIC_SIDE_EFFECTS_PM\""}}}