


{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"mental::POST_SSRI_SEXUAL_DYSFUNCTION_SS","issue_slug":"mental","doc_id":"POST_SSRI_SEXUAL_DYSFUNCTION_SS","title":"Post-SSRI Sexual Dysfunction Across Epidemiology, Mechanisms, and Management","doi":"10.62487/saimsara343e1f7e","doi_url":"https://doi.org/10.62487/saimsara343e1f7e","version":"2026-05-30","source_name":"Semantic Scholar","article_url":"https://saimsara.com/sessions/post-ssri-sexual-dysfunction-20260530-205836-343e1f7e/","image_url":"","topic_tags":"Post-SSRI Sexual Dysfunction,erectile dysfunction,genital anesthesia,sexual dysfunction,SSRI withdrawal,dopamine dysregulation,paroxetine,transcriptomic changes,quality of life,nutraceutical treatment","keywords":["Post-SSRI Sexual Dysfunction","erectile dysfunction","genital anesthesia","sexual dysfunction","SSRI withdrawal","dopamine dysregulation","paroxetine","transcriptomic changes","quality of life","nutraceutical treatment"],"metrics":{"included_all":524,"included_original":335,"reference_index":78,"total_participants":1231369},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=mental%3A%3APOST_SSRI_SEXUAL_DYSFUNCTION_SS","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3APOST_SSRI_SEXUAL_DYSFUNCTION_SS","price":{"amount":"9.00","currency":"USD","units":9,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":18281,"preview":"Results Key finding aligned to the query: The most robust and recurrent signal across the evidence base is that PSSD is a distinct, severe, and persistent syndrome characterized by a triad of profound erectile dysfunction, genital anesthesia, and loss of libido, with emerging evidence of structural changes in erectile tissue and persistent neurochemical and transcriptomic alterations in animal models. A large-scale cohort study quantified the risk, finding that serotonergic antidepressants are associated with a 3.2-fold increased odds of erectile dysfunction, with a PSSD risk of 1 in 216 treated patients (0.46%). Clinically, two retrospective analyses of an overlapping cohort of affected you…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"mental::POST_SSRI_SEXUAL_DYSFUNCTION_SS"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"9.00","currency":"USD","units":9,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=mental::POST_SSRI_SEXUAL_DYSFUNCTION_SS\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3APOST_SSRI_SEXUAL_DYSFUNCTION_SS","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3APOST_SSRI_SEXUAL_DYSFUNCTION_SS\""}}}