{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"mental::PSILOCYBIN_PM","issue_slug":"mental","doc_id":"PSILOCYBIN_PM","title":"Psilocybin and Mental Health Outcomes","doi":"10.62487/saimsara7a54f680","doi_url":"https://doi.org/10.62487/saimsara7a54f680","version":"2026-06-03","source_name":"PubMed","article_url":"https://saimsara.com/sessions/psilocybin-health-20260603-113623-7a54f680/","image_url":"","topic_tags":"psilocybin therapy,major depressive disorder,treatment-resistant depression,psychedelic-assisted psychotherapy,mental health outcomes,psilocybin biosynthesis,clinician attitudes,microdosing effects,post-traumatic stress disorder,substance misuse reduction","keywords":["psilocybin therapy","major depressive disorder","treatment-resistant depression","psychedelic-assisted psychotherapy","mental health outcomes","psilocybin biosynthesis","clinician attitudes","microdosing effects","post-traumatic stress disorder","substance misuse reduction"],"metrics":{"included_all":467,"included_original":215,"reference_index":145,"total_participants":271241797},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=mental%3A%3APSILOCYBIN_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3APSILOCYBIN_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":19965,"preview":"Results Original research topic synthesis: Topics are presented in an approximate qualitative evidence hierarchy, with topics supported by stronger study designs appearing earlier in the list, whereas topics supported mainly by lower-level evidence appear later. Mental Health Outcomes — Psilocybin-assisted therapy was associated with large and sustained reductions in depressive symptoms across multiple populations, including MDD (Cohen’s d=2.5 at week 5), TRD (Cohen’s d=2.2–2.3), and frontline healthcare workers with COVID-19-related depression (mean MADRS change −21.33 vs −9.33). Significant improvements in anxiety, PTSD, and psychological distress were observed in veterans attending psiloc…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"mental::PSILOCYBIN_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=mental::PSILOCYBIN_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3APSILOCYBIN_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=mental%3A%3APSILOCYBIN_PM\""}}}