{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::ANTICOAGULATION_PAD_PM","issue_slug":"vascular","doc_id":"ANTICOAGULATION_PAD_PM","title":"Anticoagulation in Peripheral Artery Disease","doi":"10.62487/saimsaraac354ec8","doi_url":"https://doi.org/10.62487/saimsaraac354ec8","version":"2026-04-03","source_name":"PubMed","article_url":"https://saimsara.com/sessions/peripheral-artery-disease-anticoagulation-20260129-172912-ac354ec8/","image_url":"","topic_tags":"Peripheral artery disease,Anticoagulation therapy,Rivaroxaban,Major adverse limb events,Lower extremity revascularization,Dual pathway inhibition,Major bleeding risk,Venous thromboembolism,Atrial fibrillation,Ankle-brachial index","keywords":["Peripheral artery disease","Anticoagulation therapy","Rivaroxaban","Major adverse limb events","Lower extremity revascularization","Dual pathway inhibition","Major bleeding risk","Venous thromboembolism","Atrial fibrillation","Ankle-brachial index"],"metrics":{"included_all":149,"included_original":110,"reference_index":70,"total_participants":2351292},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3AANTICOAGULATION_PAD_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AANTICOAGULATION_PAD_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":15826,"preview":"Results Key finding aligned to the query: Dual pathway inhibition (DPI) using low-dose rivaroxaban (2.5 mg twice daily) plus aspirin consistently reduces the risk of MALE and MACE in patients with chronic or post-revascularization PAD compared to aspirin alone. Across the primary randomized evidence, this regimen demonstrated a 24% reduction in MACE and a reduction in MALE ranging from 43% to 47%. However, these benefits are accompanied by a significant increase in major bleeding, primarily gastrointestinal, with hazard ratios (HR) ranging from 1.70 to 1.78. Original research topic synthesis (ordered by evidence hierarchy): Subgroups with potentially greater benefit from rivaroxaban plus asp…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::ANTICOAGULATION_PAD_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::ANTICOAGULATION_PAD_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AANTICOAGULATION_PAD_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AANTICOAGULATION_PAD_PM\""}}}