{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::ASPIRIN_VS_CLOPIDOGREL_PM","issue_slug":"vascular","doc_id":"ASPIRIN_VS_CLOPIDOGREL_PM","title":"Aspirin vs Clopidogrel","doi":"10.62487/saimsara2e3a8ec9","doi_url":"https://doi.org/10.62487/saimsara2e3a8ec9","version":"2026-04-15","source_name":"PubMed","article_url":"https://saimsara.com/sessions/aspirin-clopidogrel-20250924-152723-2e3a8ec9/","image_url":"","topic_tags":"Antiplatelet monotherapy,Ischemic stroke,Secondary prevention,Myocardial infarction,Gastrointestinal bleeding,Percutaneous coronary intervention,Platelet reactivity,CYP2C19 polymorphism,Vascular events,Dual antiplatelet therapy","keywords":["Antiplatelet monotherapy","Ischemic stroke","Secondary prevention","Myocardial infarction","Gastrointestinal bleeding","Percutaneous coronary intervention","Platelet reactivity","CYP2C19 polymorphism","Vascular events","Dual antiplatelet therapy"],"metrics":{"included_all":2755,"included_original":2319,"reference_index":116,"total_participants":9103381},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3AASPIRIN_VS_CLOPIDOGREL_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AASPIRIN_VS_CLOPIDOGREL_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":17127,"preview":"Results Study-Level Evidence Map: Favours aspirin ΣN=409072 (4%) Favours clopidogrel ΣN=620952 (7%) Neutral ΣN=8073357 (89%) Key finding aligned to the query: Clopidogrel monotherapy demonstrates superior or non-inferior efficacy in long-term secondary prevention after PCI and in patients with symptomatic atherosclerosis, significantly reducing composite ischemic events compared to aspirin. Representative hazard ratios (HR) for primary composite endpoints range from 0.71 (95% CI 0.54-0.93) in high-risk post-PCI populations to 0.86 (95% CI 0.77-0.96) during extended 10-year follow-up. However, clopidogrel efficacy is constrained by high on-treatment platelet reactivity (HTPR) linked to CYP2C1…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::ASPIRIN_VS_CLOPIDOGREL_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::ASPIRIN_VS_CLOPIDOGREL_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AASPIRIN_VS_CLOPIDOGREL_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AASPIRIN_VS_CLOPIDOGREL_PM\""}}}