{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::CKD_VASC_CALC_SS","issue_slug":"vascular","doc_id":"CKD_VASC_CALC_SS","title":"Chronic Kidney Disease and Vascular Calcification","doi":"10.62487/saimsara449d96eb","doi_url":"https://doi.org/10.62487/saimsara449d96eb","version":"2026-03-12","source_name":"PubMed","article_url":"https://saimsara.com/sessions/chronic-kidney-disease-vascular-calcification-20260312-123411-449d96eb/","image_url":"","topic_tags":"Chronic kidney disease,Vascular calcification,Vascular smooth muscle cells,Calciprotein particles,Uremic toxins,Biomarkers,Inflammation,Runx2,Magnesium,MicroRNAs","keywords":["Chronic kidney disease","Vascular calcification","Vascular smooth muscle cells","Calciprotein particles","Uremic toxins","Biomarkers","Inflammation","Runx2","Magnesium","MicroRNAs"],"metrics":{"included_all":1349,"included_original":1230,"reference_index":212,"total_participants":405323},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3ACKD_VASC_CALC_SS","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3ACKD_VASC_CALC_SS","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":17199,"preview":"Results Study characteristics Key finding aligned to the query: Vascular calcification in chronic kidney disease is primarily driven by a complex interplay of uremic toxins, inflammation, and cellular phenotypic changes, leading to the osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs). Specific mechanisms include the activation of inflammatory pathways (e.g., NLRP3 inflammasome, NF-κB signaling) by uremic toxins like trimethylamine N-oxide (TMAO) and lipopolysaccharide from gut bacteria, oxidative stress mediated by elevated 4-hydroxynonenal (4-HNE) carbonylating Runx2, and epigenetic modifications like indoxyl sulfate-induced Klotho gene hypermethylation. This pathol…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::CKD_VASC_CALC_SS"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::CKD_VASC_CALC_SS\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3ACKD_VASC_CALC_SS","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3ACKD_VASC_CALC_SS\""}}}