


{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::GENDER_AFFIRMING_HORMONE_CARDIOVASCULAR_RISK_SS","issue_slug":"vascular","doc_id":"GENDER_AFFIRMING_HORMONE_CARDIOVASCULAR_RISK_SS","title":"Gender-Affirming Hormone Therapy and Cardiovascular Risk in Transgender People","doi":"10.62487/saimsara9d970a85","doi_url":"https://doi.org/10.62487/saimsara9d970a85","version":"2026-05-24","source_name":"Semantic Scholar","article_url":"https://saimsara.com/sessions/gender-affirming-hormone-therapy-cardiovascular-risk-20260524-153054-9d970a85/","image_url":"","topic_tags":"Gender-affirming hormone therapy,Cardiovascular risk,Transgender health,Estradiol,Testosterone therapy,Atherosclerosis,Endothelial dysfunction,Venous thromboembolism,Myocardial infarction,Inflammation","keywords":["Gender-affirming hormone therapy","Cardiovascular risk","Transgender health","Estradiol","Testosterone therapy","Atherosclerosis","Endothelial dysfunction","Venous thromboembolism","Myocardial infarction","Inflammation"],"metrics":{"included_all":649,"included_original":319,"reference_index":114,"total_participants":15735475},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3AGENDER_AFFIRMING_HORMONE_CARDIOVASCULAR_RISK_SS","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AGENDER_AFFIRMING_HORMONE_CARDIOVASCULAR_RISK_SS","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":27221,"preview":"Results Key finding aligned to the query: The evidence reveals a consistent, sex-hormone-dependent divergence in cardiovascular risk profiles: masculinizing GAHT (testosterone) in transgender men is predominantly associated with adverse cardiometabolic changes—including increased low-density lipoprotein cholesterol (LDL-C), decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure, increased arterial stiffness, and impaired endothelial-dependent vasodilation—while feminizing GAHT (estradiol with anti-androgens) in transgender women yields mixed effects, with some studies indicating increased venous thromboembolism (VTE) risk, adverse inflammatory and coagulation profile…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::GENDER_AFFIRMING_HORMONE_CARDIOVASCULAR_RISK_SS"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::GENDER_AFFIRMING_HORMONE_CARDIOVASCULAR_RISK_SS\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AGENDER_AFFIRMING_HORMONE_CARDIOVASCULAR_RISK_SS","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AGENDER_AFFIRMING_HORMONE_CARDIOVASCULAR_RISK_SS\""}}}