{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::GLP_1_CARDIOVASCULAR_EPMC","issue_slug":"vascular","doc_id":"GLP_1_CARDIOVASCULAR_EPMC","title":"GLP-1 and Cardiovascular Effects","doi":"10.62487/saimsarafcc6e977","doi_url":"https://doi.org/10.62487/saimsarafcc6e977","version":"2026-04-21","source_name":"Europe PMC","article_url":"https://saimsara.com/sessions/glp-cardiovascular-20260219-101232-fcc6e977/","image_url":"","topic_tags":"GLP-1 receptor agonists,Major adverse cardiovascular events,Type 2 diabetes mellitus,Heart failure hospitalization,Atrial fibrillation,Obesity,Myocardial infarction,Stroke,Peripheral artery disease,Cardiorenal outcomes","keywords":["GLP-1 receptor agonists","Major adverse cardiovascular events","Type 2 diabetes mellitus","Heart failure hospitalization","Atrial fibrillation","Obesity","Myocardial infarction","Stroke","Peripheral artery disease","Cardiorenal outcomes"],"metrics":{"included_all":3301,"included_original":948,"reference_index":155,"total_participants":24310384},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3AGLP_1_CARDIOVASCULAR_EPMC","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AGLP_1_CARDIOVASCULAR_EPMC","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":21564,"preview":"Results Study-Level Evidence Map: GLP-1 → cardiovascular Outcome Favorable ΣN=9113625 (37%) Unfavorable ΣN=1135326 (5%) Neutral ΣN=14061433 (58%) Key finding aligned to the query: GLP-1RA therapy consistently reduces the risk of MACE, cardiovascular mortality, and stroke across a broad spectrum of patients, including those with T2DM, obesity, and established ASCVD. This protection is mediated through a systems-level integration of improved lipid handling, reduced systemic inflammation (e.g., lower C-reactive protein levels), and direct enhancement of endothelial function. Representative outcomes include a hazard ratio (HR) for MACE as low as 0.466 in high-risk ASCVD populations and a 26% to…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::GLP_1_CARDIOVASCULAR_EPMC"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::GLP_1_CARDIOVASCULAR_EPMC\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AGLP_1_CARDIOVASCULAR_EPMC","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AGLP_1_CARDIOVASCULAR_EPMC\""}}}