{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::INFLAMMATION_CAROTID_PM","issue_slug":"vascular","doc_id":"INFLAMMATION_CAROTID_PM","title":"Inflammation in Carotid Stenosis","doi":"10.62487/saimsarab5b2e2ef","doi_url":"https://doi.org/10.62487/saimsarab5b2e2ef","version":"2026-04-17","source_name":"PubMed","article_url":"https://saimsara.com/sessions/carotid-stenosis-inflammation-20260130-060214-b5b2e2ef/","image_url":"","topic_tags":"Carotid artery stenosis,Plaque inflammation,FDG-PET imaging,Systemic immune-inflammation index,Plaque vulnerability,Recurrent ischemic stroke,Inflammatory biomarkers,Carotid endarterectomy,Intraplaque neovascularization,Pericarotid adipose tissue","keywords":["Carotid artery stenosis","Plaque inflammation","FDG-PET imaging","Systemic immune-inflammation index","Plaque vulnerability","Recurrent ischemic stroke","Inflammatory biomarkers","Carotid endarterectomy","Intraplaque neovascularization","Pericarotid adipose tissue"],"metrics":{"included_all":546,"included_original":496,"reference_index":133,"total_participants":155393},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3AINFLAMMATION_CAROTID_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AINFLAMMATION_CAROTID_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":17657,"preview":"Results Key finding aligned to the query: Vascular and systemic inflammation serve as primary drivers of carotid plaque destabilization and are independent predictors of recurrent ischemic events, often providing superior prognostic value compared to luminal stenosis alone. Systems-level synthesis reveals that local macrophage infiltration and pro-inflammatory signaling (e.g., IL-6, TNF-α, and the IL-33/ST2 axis) promote intraplaque neovascularization and fibrous cap thinning, leading to plaque rupture and microembolization. Representative data indicates that high plaque inflammation, quantified by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) uptake, is associated with a sig…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::INFLAMMATION_CAROTID_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::INFLAMMATION_CAROTID_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AINFLAMMATION_CAROTID_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AINFLAMMATION_CAROTID_PM\""}}}