{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::INTERATRIAL_SHUNT_PM","issue_slug":"vascular","doc_id":"INTERATRIAL_SHUNT_PM","title":"Interatrial Shunt Hemodynamics and Clinical Outcomes","doi":"10.62487/saimsara46ef58f3","doi_url":"https://doi.org/10.62487/saimsara46ef58f3","version":"2026-06-03","source_name":"PubMed","article_url":"https://saimsara.com/sessions/interatrial-shunt-20260603-195654-46ef58f3/","image_url":"","topic_tags":"interatrial shunt,heart failure,patent foramen ovale,cryptogenic stroke,left atrial pressure,right-to-left shunt,transcatheter closure,pulmonary hypertension,cardiac remodeling,shunt hemodynamics","keywords":["interatrial shunt","heart failure","patent foramen ovale","cryptogenic stroke","left atrial pressure","right-to-left shunt","transcatheter closure","pulmonary hypertension","cardiac remodeling","shunt hemodynamics"],"metrics":{"included_all":611,"included_original":502,"reference_index":218,"total_participants":77138},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3AINTERATRIAL_SHUNT_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AINTERATRIAL_SHUNT_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":34064,"preview":"Results Key finding aligned to the query: The clinical impact of an interatrial shunt is profoundly dependent on the direction of flow and the underlying hemodynamic substrate, with a left-to-right shunt providing a therapeutic benefit in specific HF phenotypes by unloading the left atrium, while a right-to-left shunt represents a pathological pathway for hypoxemia and paradoxical embolism. The most replicated and query-defining signal across the evidence is this therapeutic dichotomy, demonstrated most robustly in HF where transcatheter interatrial shunt device implantation showed a signal for benefit in patients with reduced left ventricular ejection fraction (LVEF) but potential harm in t…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::INTERATRIAL_SHUNT_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::INTERATRIAL_SHUNT_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AINTERATRIAL_SHUNT_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AINTERATRIAL_SHUNT_PM\""}}}