{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::MEDICATION_AAA_PM","issue_slug":"vascular","doc_id":"MEDICATION_AAA_PM","title":"Medical Management of Abdominal Aortic Aneurysm","doi":"10.62487/saimsara81bc962f","doi_url":"https://doi.org/10.62487/saimsara81bc962f","version":"2026-04-12","source_name":"PubMed","article_url":"https://saimsara.com/sessions/abdominal-aortic-aneurysm-medication-20260213-140326-81bc962f/","image_url":"","topic_tags":"Abdominal aortic aneurysm,Statin therapy,Metformin,Antiplatelet agents,Antihypertensive medication,Aneurysm growth rate,Beta-blockers,VSMC senescence,SIRT1 pathway,Perioperative mortality,AAA","keywords":["Abdominal aortic aneurysm","Statin therapy","Metformin","Antiplatelet agents","Antihypertensive medication","Aneurysm growth rate","Beta-blockers","VSMC senescence","SIRT1 pathway","Perioperative mortality","AAA"],"metrics":{"included_all":107,"included_original":90,"reference_index":69,"total_participants":934696},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3AMEDICATION_AAA_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AMEDICATION_AAA_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":15323,"preview":"Results Key finding aligned to the query: The most robust evidence across human cohorts indicates that optimal medical management, specifically the combination of statins and antiplatelet agents, is consistently associated with significantly improved long-term survival and reduced cardiovascular mortality in patients with AAA. Mechanistically, animal and experimental models suggest that attenuating vascular smooth muscle cell (VSMC) senescence through pathways such as β2AR/cAMP/SIRT1 and inhibiting inflammatory cascades like the NLRP3-caspase-1 inflammasome are primary drivers for reducing AAA formation and expansion. Representative clinical data show that statin use alone can reduce the ris…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::MEDICATION_AAA_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::MEDICATION_AAA_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AMEDICATION_AAA_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3AMEDICATION_AAA_PM\""}}}