{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::PAD_AMPUTATION_PM","issue_slug":"vascular","doc_id":"PAD_AMPUTATION_PM","title":"Peripheral Artery Disease and Amputation","doi":"10.62487/saimsara20fbe2d9","doi_url":"https://doi.org/10.62487/saimsara20fbe2d9","version":"2026-05-01","source_name":"PubMed","article_url":"https://saimsara.com/sessions/pad-amputation-20260501-182232-20fbe2d9/","image_url":"","topic_tags":"Peripheral Artery Disease,Lower Extremity Amputation,Diabetes Mellitus,Major Adverse Limb Events,Revascularization,Socioeconomic Disparities,Statin Therapy,Inflammatory Biomarkers,Regional Variation,Tissue Loss","keywords":["Peripheral Artery Disease","Lower Extremity Amputation","Diabetes Mellitus","Major Adverse Limb Events","Revascularization","Socioeconomic Disparities","Statin Therapy","Inflammatory Biomarkers","Regional Variation","Tissue Loss"],"metrics":{"included_all":1035,"included_original":908,"reference_index":183,"total_participants":17638901},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3APAD_AMPUTATION_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APAD_AMPUTATION_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":26308,"preview":"Results Key finding aligned to the query: Peripheral artery disease (PAD) is the primary driver of major limb loss, particularly when comorbid with diabetes mellitus (DM), which increases the odds of amputation up to 51.8-fold compared to DM alone. The risk of major adverse limb events (MALE) is consistently mitigated by high-intensity statin therapy, and incretin-based therapies including GLP-1 receptor agonists and tirzepatide, whereas the association with sodium-glucose cotransporter-2 inhibitors (SGLT2i) remains heterogeneous, showing both increased and decreased risks across different populations. Original research topic synthesis (ordered by evidence hierarchy): Antithrombotic intensif…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::PAD_AMPUTATION_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::PAD_AMPUTATION_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APAD_AMPUTATION_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APAD_AMPUTATION_PM\""}}}