{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::PAD_PATHOPHYSIOLOGY_SS","issue_slug":"vascular","doc_id":"PAD_PATHOPHYSIOLOGY_SS","title":"Peripheral Artery Disease and Pathophysiology","doi":"10.62487/saimsara8ffb6594","doi_url":"https://doi.org/10.62487/saimsara8ffb6594","version":"2026-03-10","source_name":"Semantic Scholar","article_url":"https://saimsara.com/sessions/peripheral-artery-disease-pathophysiology-20260308-215923-8ffb6594/","image_url":"","topic_tags":"Peripheral artery disease,Pathophysiology,Endothelial dysfunction,Oxidative stress,Mitochondrial dysfunction,Insulin resistance,Inflammation,Atherosclerosis,Vascular remodeling,Biomarkers","keywords":["Peripheral artery disease","Pathophysiology","Endothelial dysfunction","Oxidative stress","Mitochondrial dysfunction","Insulin resistance","Inflammation","Atherosclerosis","Vascular remodeling","Biomarkers"],"metrics":{"included_all":189,"included_original":100,"reference_index":62,"total_participants":1005011},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3APAD_PATHOPHYSIOLOGY_SS","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APAD_PATHOPHYSIOLOGY_SS","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":10212,"preview":"Results Key finding aligned to the query: The pathophysiology of peripheral artery disease is characterized by a pervasive endothelial dysfunction, driven by chronic inflammation, oxidative stress, and metabolic dysregulation, leading to impaired angiogenesis and localized tissue damage. This multifaceted process is evidenced by significantly lower circulating soluble endothelial protein C receptor (sEPCR) levels in PAD patients, compromised nitric oxide (NO) bioavailability, and the critical involvement of mitochondrial dysfunction, particularly suppressed Complex I mitochondrial gene expression in endothelial cells. These systemic and localized impairments contribute to reduced blood flow…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::PAD_PATHOPHYSIOLOGY_SS"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::PAD_PATHOPHYSIOLOGY_SS\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APAD_PATHOPHYSIOLOGY_SS","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APAD_PATHOPHYSIOLOGY_SS\""}}}