{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::PCSK9_BASE_EDITING_SS","issue_slug":"vascular","doc_id":"PCSK9_BASE_EDITING_SS","title":"PCSK9 Base Editing, In Vivo Gene Therapy, and Durable LDL-C Lowering","doi":"10.62487/saimsarabcdd5697","doi_url":"https://doi.org/10.62487/saimsarabcdd5697","version":"2026-05-20","source_name":"Semantic Scholar","article_url":"https://saimsara.com/sessions/pcsk9-base-editing-20260520-180050-bcdd5697","image_url":"","topic_tags":"PCSK9,Base editing,Adenine base editors,Lipid nanoparticles,Hypercholesterolemia,LDL cholesterol,Gene therapy,In vivo gene editing,Cardiovascular disease,Cholesterol reduction","keywords":["PCSK9","Base editing","Adenine base editors","Lipid nanoparticles","Hypercholesterolemia","LDL cholesterol","Gene therapy","In vivo gene editing","Cardiovascular disease","Cholesterol reduction"],"metrics":{"included_all":125,"included_original":89,"reference_index":51,"total_participants":2172},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3APCSK9_BASE_EDITING_SS","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APCSK9_BASE_EDITING_SS","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":10936,"preview":"Results Key finding aligned to the query: Across preclinical models and early-phase human trials, single-dose in vivo base editing targeting the PCSK9 gene consistently achieves highly efficient, durable gene disruption and therapeutic reductions in circulating PCSK9 and LDL-C. In animal models, lipid nanoparticle (LNP)-mediated or viral vector-mediated adenine base editors (ABEs) demonstrate liver editing efficiencies ranging from 12% to 70%, translating to stable plasma PCSK9 reductions of up to 95% and LDL-C lowering of up to 69% for over a year. Early clinical evaluations of investigational base-editing therapeutics, such as YOLT-101, corroborate these findings in human patients with het…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::PCSK9_BASE_EDITING_SS"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::PCSK9_BASE_EDITING_SS\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APCSK9_BASE_EDITING_SS","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3APCSK9_BASE_EDITING_SS\""}}}