


{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"vascular::STEM_CELL_THERAPY_CARDIOVASCULAR_PM","issue_slug":"vascular","doc_id":"STEM_CELL_THERAPY_CARDIOVASCULAR_PM","title":"Stem Cell Therapy for Cardiovascular Disease, Heart Failure, and Refractory Angina","doi":"10.62487/saimsarac42ee27d","doi_url":"https://doi.org/10.62487/saimsarac42ee27d","version":"2026-05-03","source_name":"PubMed","article_url":"https://saimsara.com/sessions/stem-cell-therapy-cardiovascular-disease-20260503-140044-c42ee27d/","image_url":"","topic_tags":"Stem cell therapy,Cardiovascular disease,Myocardial infarction,Heart failure,Mesenchymal stem cells,Induced pluripotent stem cells,Regenerative medicine,Cardiotoxicity,Hematopoietic stem cell transplantation,Angiogenesis","keywords":["Stem cell therapy","Cardiovascular disease","Myocardial infarction","Heart failure","Mesenchymal stem cells","Induced pluripotent stem cells","Regenerative medicine","Cardiotoxicity","Hematopoietic stem cell transplantation","Angiogenesis"],"metrics":{"included_all":367,"included_original":169,"reference_index":165,"total_participants":547679},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=vascular%3A%3ASTEM_CELL_THERAPY_CARDIOVASCULAR_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3ASTEM_CELL_THERAPY_CARDIOVASCULAR_PM","price":{"amount":"7.00","currency":"USD","units":7,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":26445,"preview":"Results Key finding aligned to the query: Stem cell therapy, particularly utilizing CD34+ and mesenchymal lineages, showed selected clinical signals, including LVEF improvement up to approximately 8.7% in one ischemic heart disease/CABG setting, and significant reductions in angina frequency. This regenerative potential is primarily mediated through paracrine signaling, neovascularization, and the modulation of inflammatory responses. However, therapeutic efficacy is critically limited by patient-specific factors such as diabetes-induced impairment of cell mobilization (r = -0.82) and the low myocardial retention of delivered cells (often","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"vascular::STEM_CELL_THERAPY_CARDIOVASCULAR_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"7.00","currency":"USD","units":7,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=vascular::STEM_CELL_THERAPY_CARDIOVASCULAR_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3ASTEM_CELL_THERAPY_CARDIOVASCULAR_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=vascular%3A%3ASTEM_CELL_THERAPY_CARDIOVASCULAR_PM\""}}}