{"ok":true,"api":{"name":"SAIMSARA Evidence Object Discovery API","version":"v1"},"mode":"doc_key","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"object":{"object_type":"saimsara_evidence_object_metadata","doc_key":"visceral::PROLONGED_FASTING_PM","issue_slug":"visceral","doc_id":"PROLONGED_FASTING_PM","title":"Prolonged Fasting","doi":"10.62487/saimsara93074bf6","doi_url":"https://doi.org/10.62487/saimsara93074bf6","version":"2026-05-25","source_name":"PubMed","article_url":"https://saimsara.com/sessions/prolonged-fasting-20260222-221118-93074bf6/","image_url":"https://youtu.be/et3ooxWs1oI","topic_tags":"Prolonged fasting,Water-only fasting,Metabolic adaptation,Ketogenesis,Insulin resistance,Lipid oxidation,Gut microbiota,Systemic proteomics,IGF-1 signaling,Oxidative stress","keywords":["Prolonged fasting","Water-only fasting","Metabolic adaptation","Ketogenesis","Insulin resistance","Lipid oxidation","Gut microbiota","Systemic proteomics","IGF-1 signaling","Oxidative stress"],"metrics":{"included_all":1513,"included_original":1406,"reference_index":335,"total_participants":378780},"discover_url":"https://saimsara.com/api/v1/discover.php?doc_key=visceral%3A%3APROLONGED_FASTING_PM","paid_evidence_url":"https://saimsara.com/api/v1/evidence.php?doc_key=visceral%3A%3APROLONGED_FASTING_PM","price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"payment_methods":["api_key","stripe_checkout","object_grant","x402"],"text_length":45096,"preview":"Results Key finding aligned to the query: Across the included studies, the central recurrent finding is that prolonged fasting induces a coordinated whole-body fuel transition from glucose and glycogen reliance toward lipid oxidation, ketogenesis, gluconeogenesis, endocrine remodeling, immune modulation, and organ-specific adaptation, with effects that are highly context dependent rather than uniformly beneficial or harmful. Human and animal studies repeatedly described falling glucose and insulin, rising counterregulatory or fasting-adaptive signals, greater fat oxidation, ketone use, and broad molecular remodeling, including systemic proteomic changes after a 7-day water-only fast with res…","trust_label":"machine_generated_human_reviewed","editorial_verification":{"status":"human_reviewed","trust_label":"machine_generated_human_reviewed","method":"World ID proof-of-human editorial account","scope":["clinical_integrity","reference_quality","scientific_coherence"],"verification_note":"This Evidence Object is machine-generated and human-reviewed. World ID is used to verify that editorial oversight was submitted by a unique human account.","does_not_mean":"World ID verifies proof-of-human editorial oversight; it does not independently certify the scientific truth of every claim."},"checkout":{"method":"POST","url":"https://saimsara.com/create_checkout_session.php","content_type":"application/x-www-form-urlencoded","params":{"plan":"evidence_object","doc_key":"visceral::PROLONGED_FASTING_PM"},"optional_params":{"customer_email":"user@example.com"},"price":{"amount":"5.00","currency":"USD","units":5,"unit_amount":"1.00"},"curl_example":"curl -X POST https://saimsara.com/create_checkout_session.php -d \"plan=evidence_object\" -d \"doc_key=visceral::PROLONGED_FASTING_PM\" -d \"customer_email=user@example.com\""},"access_after_payment":{"header":"X-SAIMSARA-Payment-Proof","endpoint":"https://saimsara.com/api/v1/evidence.php?doc_key=visceral%3A%3APROLONGED_FASTING_PM","curl_example":"curl -H \"X-SAIMSARA-Payment-Proof: YOUR_PAYMENT_PROOF_TOKEN\" \"https://saimsara.com/api/v1/evidence.php?doc_key=visceral%3A%3APROLONGED_FASTING_PM\""}}}