SAIMSARA Journal

Machine Generated Science • ISSN 3054-3991

Atherosclerosis and Treatment: Scoping Review with ☸️SAIMSARA.

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Vascular Health

Issue 1, Volume 1, 2026

Editorial note
• Last update: 2026-03-16 20:12:49
What is this paper about
The main message of this paper is that current treatment of atherosclerosis relies mainly on standard preventive therapies—cholesterol lowering, combination lipid therapy, and blood-pressure control—whereas future treatment may come from more precise targeting of inflammation, endothelial injury, oxidative stress, immune pathways, and plaque biology. The review maps 47 original research topics, from combination therapies to cannabinoid receptor modulation, and 10 recurrent directions in the non-original literature, from lipid reduction to personalized imaging of plaque burden.
Additional notes
Clinical & Methodological Validation

DOI: 10.62487/saimsara367e2f7a

Abstract: The aim of this paper is to systematically synthesize recent evidence concerning the mechanisms of atherosclerosis and the efficacy of various treatment approaches, as extracted from a structured summary of scientific literature. The review utilises 1015 original studies with 2628810 total participants (topic deduplicated ΣN). This scoping review maps a broad and rapidly expanding treatment landscape for atherosclerosis, with the strongest and most directly actionable human evidence clustering around established lipid-lowering and blood-pressure–lowering strategies, including combination lipid therapy and antihypertensive treatment effects on vascular outcomes. Across the wider evidence map—dominated by preclinical studies—therapeutic signals repeatedly converged on inflammation control, endothelial protection, immune modulation, oxidative stress reduction, and targeted delivery approaches (including nanomedicine and device/energy-based modalities) as routes to reduce plaque burden and improve plaque stability. At the same time, interpretation is limited by the imbalance toward non-human mechanistic studies and the lack of formal critical appraisal, which together temper confidence in near-term clinical translation. Practically, the synthesis supports optimizing implementation of proven preventive therapies and risk identification (e.g., improving statin initiation/intensification through screening workflows) while using emerging mechanistic targets to prioritize translational pipelines. Future research should focus on well-designed human trials that test the most consistently supported anti-inflammatory and targeted-delivery strategies and clarify which patient subgroups benefit most.

Keywords: Atherosclerosis treatment; Inflammation; Oxidative stress; Gut microbiome; Immunomodulation; Gene expression regulation; Pharmacological targets; Anticoagulant therapy; Plaque regression; Endothelial dysfunction

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