Y Chromosome Loss: Systematic Review with ☸️SAIMSARA

Reference Index (95)

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[43] Bladder Cancer, Loss of Y Chromosome, and New Opportunities for Immunotherapy. — https://doi.org/10.1007/s12325-023-02758-w
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[45] Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure - interaction between loss of Y chromosome and clonal haematopoiesis. — https://doi.org/10.1002/ejhf.3778
[46] Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance. — https://doi.org/10.1002/gcc.23260
[47] Impact of Y chromosome loss on the risk of Parkinson's disease and progression. — https://doi.org/10.1016/j.ebiom.2025.105769
[50] Organochlorine pesticide use and mosaic loss of chromosome Y in a study of male farmers. — https://doi.org/10.1016/j.envres.2025.121539
[51] Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes. — https://doi.org/10.1038/s41591-026-04213-z
[52] Complete or partial loss of the Y chromosome in an unselected cohort of 865 non-vasectomized, azoospermic men. — https://doi.org/10.1186/s12610-023-00212-z
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[68] Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion. — https://doi.org/10.1158/2159-8290.cd-rw2023-102
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[78] Disruption of the epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure. — https://doi.org/10.1038/s44161-024-00441-z
[80] Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2. — https://doi.org/10.1038/s42003-024-05805-6
[91] Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health. — https://doi.org/10.1152/physiol.00008.2023
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[149] Y Chromosome Loss is a Frequent Event in Barrett's Adenocarcinoma and Associated with Poor Outcome. — https://doi.org/10.3390/cancers12071743
[150] Phased Assembly of Neo-Sex Chromosomes Reveals Extensive Y Degeneration and Rapid Genome Evolution in Rumex hastatulus. — https://doi.org/10.1093/molbev/msae074
[153] Genetic association of mosaic loss of chromosome Y with prostate cancer in men of European and East Asian ancestries: a Mendelian randomization study. — https://doi.org/10.3389/fragi.2023.1176451
[155] Loss of Y chromosome: An emerging next-generation biomarker for disease prediction and early detection? — https://doi.org/10.1016/j.mrrev.2021.108389
[173] Loss of chromosome Y in primary tumors. — https://doi.org/10.1016/j.cell.2023.06.006
[179] Basal-like subtype of esophageal adenocarcinoma and it's morphological, molecular and clinical characteristics. — https://doi.org/10.1038/s41598-025-08721-9
[186] Y Chromosome Genomic Variations and Biological Significance in Human Diseases and Health. — https://doi.org/10.1159/000531933
[193] Selective loss of Y chromosomes in lung adenocarcinoma modulates the tumor immune environment through cancer/testis antigens — https://doi.org/10.1101/2024.09.19.613876
[197] Eighty million years of rapid evolution of the primate Y chromosome. — https://doi.org/10.1038/s41559-022-01974-x
[199] Y chromosome loss in cancer drives growth by evasion of adaptive immunity — https://doi.org/10.1038/s41586-023-06234-x
[200] High elevation increases the risk of Y chromosome loss in Alpine skink populations with sex reversal. — https://doi.org/10.1038/s41437-021-00406-z
[220] DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer´s disease. — https://doi.org/10.1007/s00018-025-05618-8
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[243] Insights into brain tumor diagnosis: exploring <i>in situ</i> hybridization techniques. — https://doi.org/10.3389/fneur.2024.1393572
[259] Association of Mosaic Loss of Chromosome Y with Lung Cancer Risk and Prognosis in a Chinese Population. — https://doi.org/10.1016/j.jtho.2018.09.013
[264] Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank. — https://doi.org/10.1038/s41598-018-30759-1
[278] Tumor Predisposing Post-Zygotic Chromosomal Alterations in Bladder Cancer-Insights from Histologically Normal Urothelium. — https://doi.org/10.3390/cancers16050961
[279] Physiology in Perspective. — https://doi.org/10.1152/physiol.00014.2023
[284] Loss of Y chromosome at the interface between aging and Alzheimer's disease. — https://doi.org/10.1007/s00018-021-03935-2
[296] Microdeletion of Y chromosome as a cause of recurrent pregnancy loss. — https://doi.org/10.4103/0974-1208.165145
[302] Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes. — https://doi.org/10.1016/j.celrep.2022.110636
[309] Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. — https://doi.org/10.1038/ng.3821
[316] Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men. — https://doi.org/10.1007/s00439-017-1799-2
[320] Loss of the Y chromosome predicts a high relapse risk in younger adult male patients with t(8;21) acute myeloid leukemia on high-dose cytarabine consolidation therapy: a retrospective multicenter study. — https://doi.org/10.1080/10428194.2019.1683734
[356] Mutagenesis. Smoking is associated with mosaic loss of chromosome Y. — https://doi.org/10.1126/science.1262092
[363] Y chromosome loss in male patients with primary biliary cirrhosis. — https://doi.org/10.1016/j.jaut.2012.12.008
[365] Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases — https://doi.org/10.1101/2023.06.17.23289722
[367] Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease. — https://doi.org/10.1016/j.ajhg.2016.05.014
[376] Association of Y chromosome AZF region microdeletions with recurrent miscarriage in Iranian couples: A case-control study. — https://doi.org/10.1002/mgg3.2392
[408] Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. — https://doi.org/10.1038/ng.2966
[419] Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis. — https://doi.org/10.1016/j.jaut.2011.11.011
[447] Immune cells lacking Y chromosome show dysregulation of autosomal gene expression. — https://doi.org/10.1007/s00018-021-03822-w
[474] Y disruption, autosomal hypomethylation and poor male lung cancer survival — https://doi.org/10.1101/2020.06.17.20132951
[477] GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health. — https://doi.org/10.1038/s41467-021-24504-y
[499] The evolutionary history of human and chimpanzee Y-chromosome gene loss. — https://doi.org/10.1093/molbev/msm002
[536] Genetic Predisposition to Mosaic Chromosomal Loss Is Associated With Functional Outcome After Ischemic Stroke. — https://doi.org/10.1212/nxg.0000000000000634
[541] Loss of Y in leukocytes as a risk factor for critical COVID-19 in men. — https://doi.org/10.1186/s13073-022-01144-5
[576] Prospective evaluation of prognostic impact of KIT mutations on acute myeloid leukemia with RUNX1-RUNX1T1 and CBFB-MYH11. — https://doi.org/10.1182/bloodadvances.2019000709
[586] Y chromosome losses are exceedingly rare in prostate cancer and unrelated to patient age. — https://doi.org/10.1002/pros.21492
[592] Dynamic transposable element accumulation in the nascent sex chromosomes of papaya. — https://doi.org/10.4161/mge.23462
[601] Gene loss on Y chromosomes: a consequence of purifying selection? — https://doi.org/10.4161/fly.4.4.12669
[650] Muller's ratchet and the degeneration of the Drosophila miranda neo-Y chromosome. — https://doi.org/10.1534/genetics.109.112789
[669] Genetic considerations in the patient with Turner syndrome--45,X with or without mosaicism. — https://doi.org/10.1016/j.fertnstert.2012.08.021

Y Chromosome Loss: Systematic Review with ☸️SAIMSARA

Longevity

Issue 2, Volume 1, 2026

DOI: 10.62487/saimsaraab15307b

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