SAIMSARA Journal

Machine Generated Science • ISSN 3054-3991

Coffee: Scoping Review with ☸️SAIMSARA.

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Issue 2, Volume 1, 2026

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Editorial note
• Last update: 2026-03-23 11:59:17
What is this paper about
This paper shows that coffee is not simply “good” or “bad” for health: moderate intake is repeatedly linked with lower risks of stroke, dementia, diabetes, and death, while higher intake and certain coffee types can also carry harm signals. Read the full paper to see where the benefits look most convincing, where the evidence becomes conflicting, and which patients may need more caution than the usual “2–3 cups a day” message suggests.
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DOI: 10.62487/saimsara648ea100

Abstract: This paper aims to systematically synthesize the findings from recent human studies on coffee consumption to identify its varied impacts on health outcomes, including chronic diseases, metabolic function, neurological health, and overall well-being. The review utilises 4049 original studies with 55611456 total participants (topic deduplicated ΣN). Across the mapped human evidence, the most consistent signal is that moderate coffee intake—often around 2–3 cups/day—is associated with lower risks of major outcomes such as stroke and dementia and lower total mortality. This pattern coexists with important qualifiers: higher intakes (e.g., >4 cups/day) and certain outcomes or subgroups show potential harm signals, including increased odds of ischemic stroke in one study, and ocular risk signals in glaucoma-related analyses. Beyond long-term disease associations, coffee also appears to have practical, near-term applications, such as supporting postoperative recovery and reducing pain after cesarean section, while adverse effects like insomnia remain commonly reported. Differences by coffee type and preparation recur across domains (e.g., instant vs brewed; caffeinated vs decaffeinated), suggesting that “coffee” is not a uniform exposure and that patient counseling should emphasize moderation and preparation choices alongside individual susceptibility. Future research should prioritize standardized exposure measurement and head-to-head comparisons of preparation/type, alongside well-designed dose-response trials and genetically informed analyses to clarify where observed associations are most likely to be robust and clinically actionable.
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Keywords: Caffeine; Cancer risk; Metabolic health; Cardiovascular health; Neurological effects; Gastrointestinal health; Immune system; Inflammation; Coffee use disorder; Genetic studies

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