SAIMSARA Journal

Machine Generated Science • ISSN 3054-3991

Coffee and Longevity: Scoping Review with ☸️SAIMSARA.

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Longevity

Issue 2, Volume 1, 2026

Editorial note
• Last update: 2026-03-22 21:32:58
What is this paper about
This paper shows that coffee is not a proven anti-aging therapy, yet the mapped evidence still suggests a biologically plausible link to longer survival through oxidative-stress and insulin/IGF-1 pathways, with human data pointing to modest benefit rather than clear harm. Read the full text to see where the real signal lies, which findings are only indirect or genotype-specific, and why the apparent longevity story of coffee is much more nuanced than popular health claims suggest.

DOI: 10.62487/saimsarab9937bbd

Abstract: To synthesize, using only the structured extraction summary provided, the evidence linking coffee and coffee-related compounds with longevity, survival, and aging-related outcomes across human and experimental studies. The review utilises 35 original studies with 31872 total participants (topic deduplicated ΣN). Overall, this evidence map suggests that coffee has a plausible but not definitive relationship with longevity, with the clearest human signal being an association between a coffee-containing Japanese dietary pattern and lower all-cause mortality (HR 0.91, 95% CI 0.83–0.99) plus 10.2 months longer median survival time, alongside an inverse relation between coffee consumption and 25-year survival in Dutch men. Mechanistic and model-organism findings support a role for oxidative stress modulation and insulin/IGF-1–related pathways, as coffee infusions, coffee silverskin extract, and coffee-derived phenolics extended lifespan or stress resistance in yeast and C. elegans. At the same time, the mapped literature highlights important heterogeneity, including null associations for cognitive decline and telomere length, an adverse L-shaped association with serum α-Klotho, and possible harms in genotype-specific or high-dose contexts. In practical terms, these findings do not support using coffee as a proven anti-aging intervention, but they also do not suggest that moderate habitual intake should be discouraged on longevity grounds alone in most adults. The next priority is well-designed longitudinal human research that isolates coffee exposure, clarifies dose and beverage form, and tests whether biomarker and genotype differences translate into consistent survival effects.

Keywords: Coffee consumption; Longevity; Lifespan; All-cause mortality; Aging biomarkers; Caffeine; Oxidative stress; Antioxidant activity; Telomere length; Prospective cohort

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