SAIMSARA Journal

Machine Generated Science • ISSN 3054-3991

Deep Venous Thrombosis and Risk Factors: Systematic Review with ☸️SAIMSARA.

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Vascular Health

Issue 1, Volume 1, 2026

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• Last update: 2026-03-25 20:24:29
What is this paper about
This paper shows that DVT is rarely a single-trigger event, but the end result of converging risks spanning infection, cancer, hormones, catheters, surgery, genetics, and inflammation. The full paper is worth reading because it reveals which risk factors carry the strongest clinical signal, how they cluster in real patients, and where prevention can most realistically stop thrombosis before it becomes PE or post-thrombotic syndrome.

DOI: 10.62487/saimsara05326f98


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Abstract: This paper aims to systematically review and synthesize the identified risk factors for deep venous thrombosis. The review utilises 105 original studies with 441130 total participants (naïve ΣN). Deep venous thrombosis remains a significant clinical challenge, characterized by a complex interplay of risk factors ranging from genetic predispositions to acquired conditions and iatrogenic causes. This review synthesized a broad landscape of research, highlighting that conditions like COVID-19 markedly elevate DVT risk, with reported incidences as high as 42.2% in critically ill patients. Other major contributors include cancer, certain hormonal therapies, and surgical procedures. Diagnostic tools like D-dimer and ultrasonography are crucial, while prophylaxis and early treatment are paramount for preventing severe complications like pulmonary embolism and post-thrombotic syndrome. A limitation is the heterogeneity in study designs and reported metrics, which restricts direct quantitative comparisons. Future research should prioritize the development of personalized risk assessment tools and mechanism-based therapies to improve prevention and outcomes for this pervasive condition.

Keywords: Deep Venous Thrombosis; Risk Factors; Venous Thromboembolism; Pulmonary Embolism; COVID-19; Neutrophil Extracellular Traps; Cancer; Stroke; Catheter-related thrombosis; Thrombolytic therapy

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