What is this paper about
Diabetic foot is not just a wound problem but a high-stakes collision of neuropathy, ischemia, infection, and delayed care, with a median major amputation rate of 10.3% across the mapped evidence. This review shows where the strongest signals truly are: why multidisciplinary care can cut major amputations by up to 80%, which risk factors matter most, and which emerging diagnostics and regenerative therapies may actually change outcomes.