Female Gender and Life Expectancy: Systematic Review with ☸️SAIMSARA.

Name: SAIMSARA Evidence Object longevity::FEMALE_LIFE_EXPECTANCY_PM
Creator: SAIMSARA
License: https://saimsara.com/license/

SAIMSARA

doi:10.62487/saimsara8c3bca03

SAIMSARA Journal

Machine-Readable Science • ISSN 3054-3991

Female Gender and Life Expectancy: Systematic Review with ☸️SAIMSARA.

Longevity & Public Health

Issue 2, Volume 1, 2026

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DOI: 10.62487/saimsara8c3bca03

Editorial note

• Last update: 2026-03-28 15:45:05

What is this paper about

This paper shows that women usually live longer than men, but that extra survival often comes with more years lived with disability, multimorbidity, and reduced independence rather than more healthy years. The full paper is worth reading because it shows where the female advantage remains strong, where it weakens, and which conditions and life circumstances most clearly explain the difference

Evidence preview · Did you know?

Realistic medical-science scene showing older women across generations in a longevity context.

Women live longer — but not always better

Did you know? Female life expectancy advantage at birth ranged from 3.9 to 7.6 years across global regions.

The evidence map starts with a familiar survival advantage, then shows why the meaning of that advantage is more complex.

Realistic clinical analytics scene showing an older woman, health records, and multimorbidity signals.

The hidden health paradox

Did you know? Females spent more years with multimorbidity than males: 10.77 vs 8.93 years.

Longer survival can mean more years lived with disability, frailty, dependency, or lower-quality health states.

Realistic public-health scene showing women, healthcare access, social inequality, and longevity policy.

The advantage is not guaranteed

Did you know? In Germany, the female life-expectancy gap between deprivation groups widened from 1.1 to 1.8 years.

Female longevity is shaped not only by biology, but also by poverty, healthcare access, disease burden, and gendered social conditions.

Swipe sideways on mobile · full evidence map opens after unlock

Abstract: To systematically review the scientific literature concerning female gender and life expectancy, identifying key trends, influencing factors, and associated health outcomes across diverse global populations and clinical conditions. The review utilises 771 original studies with 16636946 total participants (ΣN). This systematic review indicates that female gender is generally associated with a higher overall life expectancy, with reported sex gaps at birth often ranging from approximately 3.9 to 7.6 years. However, this longevity advantage frequently coexists with a morbidity burden consistent with the female health paradox, with women often spending more years living with multimorbidity, disability, or reduced independence despite longer total survival. The evidence also suggests that this female advantage is not uniform across conditions, as selected cardiometabolic, cardiovascular, HIV, and neurodevelopmental contexts showed narrower gaps or signals of excess female mortality or life-expectancy loss. These findings support sex-responsive prevention and care strategies aimed not only at extending lifespan but also at preserving healthy and independent years. Future research should prioritize harmonized definitions of healthy life expectancy and clarify the biological, clinical, and social mechanisms underlying situations in which the usual female survival advantage is reduced or reversed.

Keywords: Life expectancy; Gender differences; Mortality risk; Healthy life expectancy; Sex disparities; Longevity; Chronic disease burden; Disability-free life expectancy; Social determinants of health; Multimorbidity

Review Stats

Final search date and database lock: 2026-03-28 13:28:00 CET
Plan: Pro (expanded craft tokens; source: PubMed)
Source: PubMed
Total Abstracts/Papers: 46550
Downloaded Abstracts/Papers: 10000
Included original and non-original Abstracts/Papers (all): 1290
Included original Abstracts/Papers (Vote counting by direction of effect): 771
Reference Index (links used in paper): 111
Total participants (topic deduplicated ΣN): 16636946

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Reference Index (111)

[1] Sex and Gender Differences in Chronic Kidney Disease-Explained by the Brenner-Luyckx Concept of Hyperfiltration. — https://doi.org/10.3390/jcm15041654
[2] Bayesian spatiotemporal modelling of neonatal, infant and under-5 mortality (2000-2022) in 41 Asian countries: a population-level observational study. — https://doi.org/10.1136/bmjopen-2025-108632
[3] Clinical features of osteoporosis in patients with type 1 and type 2 diabetes in Türkiye: A nationwide study. — https://doi.org/10.1007/s11657-026-01677-x
[4] Working longer despite poorer health? Inequalities in healthy and unhealthy working life expectancies in South Korea. — https://doi.org/10.1080/00324728.2026.2625712
[5] Cardiovascular-Kidney-Metabolic Interplay in Patients with Atrial Fibrillation Receiving Direct Oral Anticoagulants. — https://doi.org/10.1093/europace/euag028
[6] Cohorts' Working Life Expectancies and Working Years Lost in 21 European Countries. — https://doi.org/10.1215/00703370-12472371
[7] Life expectancy in stomach cancer survivors adjusted for blood-test-based frailty: insights into biological aging. — https://doi.org/10.1016/j.archger.2026.106166
[8] Temporal and demographic trends in bipolar disorder-related mortality in the U.S. population: A 25-year nationwide analysis (1999-2023). — https://doi.org/10.1016/j.jad.2026.121389

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