SAIMSARA Journal

Machine Generated Science • ISSN 3054-3991

Semaglutide: Systematic Review with ☸️SAIMSARA.

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Issue 1, Volume 1, 2026

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• Last update: 2026-03-23 09:32:59
What is this paper about
This paper shows that semaglutide is far more than a weight-loss drug: across a vast evidence base it emerges as a multi-system therapy with meaningful effects on obesity, diabetes, cardiovascular risk, kidney disease, and even liver and neurodegenerative pathways. The full paper is worth reading because it separates the real breadth of benefit from the hype, showing where the evidence is strongest, where safety and access concerns matter, and how semaglutide may be reshaping modern metabolic medicine.

DOI: 10.62487/saimsara45190890

Abstract: The aim of this systematic review is to comprehensively evaluate the diverse therapeutic applications, safety profile, and societal impact of semaglutide, synthesizing findings from recent academic literature to identify key clinical implications and future research directions. The review utilises 1454 original studies with 15874088 total participants (naïve ΣN). Semaglutide has emerged as a highly effective and versatile therapeutic agent, demonstrating significant benefits across a broad spectrum of conditions, most notably achieving a median body weight reduction of approximately 12.4% in adults with overweight or obesity. Its established efficacy in glycemic control, substantial cardiovascular and renal protective effects, and promising applications in liver and neurodegenerative diseases underscore its transformative role in modern medicine. While generally well-tolerated, the prevalence of gastrointestinal adverse events and concerns regarding equitable access remain important considerations. Future research should focus on optimizing long-term body composition outcomes and further elucidating its neuroprotective mechanisms, ensuring that the full potential of semaglutide is realized for all eligible patients.

Keywords: Obesity; Type 2 Diabetes; Weight Loss; GLP-1 Receptor Agonists; Cardiovascular Disease; Chronic Kidney Disease; Alzheimer's Disease; Tirzepatide; Metabolic Dysfunction-Associated Steatotic Liver Disease

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