Statins are not just cholesterol drugs: across an enormous evidence base, this review shows how they may help protect healthspan and longevity by lowering recurrent vascular events and mortality, while also exposing the real trade-offs around diabetes risk, intolerance, and poor long-term adherence. The full paper is worth reading because it separates where statins most clearly extend durable cardiovascular protection from where the evidence becomes mixed, controversial, and potentially relevant to broader aging-related pathways such as inflammation, liver disease, and neurocognitive decline.
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Abstract: The aim of this scoping review is to synthesize multi-disciplinary evidence regarding the clinical outcomes, safety profiles, and determinants of adherence associated with statin medication across diverse global populations and clinical settings. The review utilises 1637 original studies with 43987683 total participants (topic deduplicated ΣN). The evidence map suggests that statin medication remains strongly associated with lower mortality and recurrent vascular events across major cardiovascular settings, with reported hazard ratios for mortality ranging from 0.38 after ischemic stroke to 0.71 in primary prevention populations. At the same time, the mapped literature highlights a consistent safety and implementation tension: new-onset diabetes and glycemic progression were repeatedly associated with statin exposure, with odds ratios up to 1.48 in postmenopausal women and a 46% increased risk reported in middle-aged men, while roughly half of patients showed suboptimal persistence within the first year. Beyond lipid lowering, the evidence supports broader anti-inflammatory, perioperative, hepatology, and selected oncology signals, but these noncardiovascular benefits were more heterogeneous and were often derived from observational or mechanistic studies rather than definitive trials. Clinically, the findings support continued emphasis on maintaining statin therapy in appropriate high-risk patients while proactively addressing adherence barriers, intolerance concerns, cost, and glycemic monitoring. Future research should prioritize better-controlled prospective studies and pragmatic trials that clarify heterogeneity in diabetes risk, muscle symptoms, neurologic associations, and potential repurposing benefits in cancer and liver disease.
Keywords: Statin; Statin medication adherence; Diabetes progression; Cardiovascular outcomes; Cancer survival; Medication discontinuation; Insulin resistance; Poststroke depression; Quality of life; Bone mineral density; Dose-response relationship; Cholesterol;
Review Stats
Final search date and database lock: 2026-04-16 22:35:22 CEST
Plan: Pro (expanded craft tokens; source: PubMed)
Source: PubMed
Total Abstracts/Papers: 2822
Downloaded Abstracts/Papers: 2822
Included original and non-original Abstracts/Papers (all): 2561
Included original Abstracts/Papers (Vote counting by direction of effect): 1637
Reference Index (links used in paper): 344
Total participants (topic deduplicated ΣN): 43987683
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[22] Strategies to Improve Statin Medication Adherence Among Patients at Risk of Cardiovascular Disease Identified Through Electronic Health Records: A Literature Review. — https://doi.org/10.3233/shti231112
[25] Statin Medication Improves Five-Year Survival Rates in Patients with Head and Neck Cancer: A Retrospective Case-Control Study of about 100,000 Patients. — https://doi.org/10.3390/cancers15123093
[34] Statin-induced dermatomyositis for the practicing dermatologist: a review of the literature. — https://doi.org/10.1111/ijd.14751
[35] Impact of preoperative statin medication on long-term outcomes after pancreatoduodenectomy for ductal adenocarcinoma: an international multicentric cross-sectional study. — https://doi.org/10.1007/s00432-023-05426-2
[36] Paradoxical effect of statin medication on depressive disorder in first-ever ischemic stroke patients: possible antidepressant-like effect prestroke and the opposite in continuous medication poststroke. — https://doi.org/10.1097/yic.0000000000000352
[41] Strategies to Address Statin Medication Intolerance Among Patients at Risk of Cardiovascular Disease Identified Through Electronic Health Records: A Literature Review and Pooled Analysis. — https://doi.org/10.3233/shti240362
[53] Cross-sectional and longitudinal associations between statin use and bone density: the Manitoba BMD registry. — https://doi.org/10.1093/jbmr/zjaf077
[54] Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review. — https://doi.org/10.1111/bcp.12339
[55] Perioperative management with antiplatelet and statin medication is associated with reduced mortality following vascular surgery. — https://doi.org/10.1016/j.jvs.2013.12.013
[58] Systematic Review of RCTs Assessing the Effectiveness of mHealth Interventions to Improve Statin Medication Adherence: Using the Behaviour-Change Technique Taxonomy to Identify the Techniques That Improve Adherence. — https://doi.org/10.3390/healthcare9101282
[59] Major Depressive Disorder (MDD) and Antidepressant Medication Are Overrepresented in High-Dose Statin Treatment. — https://doi.org/10.3389/fmed.2021.608083
[81] Association between statin medication use and improved outcomes during inpatient rehabilitation in older people. — https://doi.org/10.1093/ageing/afr159
[92] Cholesterol-lowering drugs for high-risk hypercholesterolemia patients with COVID-19 while on Paxlovid™ therapy. — https://doi.org/10.2217/fvl-2022-0060
[97] A retrospective cohort study evaluating the relationship between statin medication adherence and economic outcomes in commercial health plans. — https://doi.org/10.1016/j.jacl.2020.09.005
[101] Adherence and Persistence Among Statin Users Aged 65 Years and Over: A Systematic Review and Meta-analysis. — https://doi.org/10.1093/gerona/glx169
[104] Medication Adherence and Clinical Outcome of Fixed-Dose Combination vs. Free Combination of Angiotensin Receptor Blocker and Statin. — https://doi.org/10.1253/circj.cj-20-0966
[109] Statin Induced Autoimmune Necrotizing Myopathy (SIANM): An Alarming Adverse Event of a Familiar Medication. — https://doi.org/10.7759/cureus.22273
[111] Nutraceuticals in the management of patients with statin-associated muscle symptoms, with a note on real-world experience. — https://doi.org/10.1002/clc.22862
[122] Statin use improves survival of patients with known or suspected lower extremity artery disease on all ankle brachial index levels. — https://doi.org/10.1024/0301-1526/a001041
[130] Patient-Centered Interventions to Improve Adherence to Statins: A Narrative Synthesis of Systematically Identified Studies. — https://doi.org/10.1007/s40265-016-0640-x
[137] Relationships between beliefs about statins and non-adherence in inpatients from Northwestern China: a cross-sectional survey. — https://doi.org/10.3389/fphar.2023.1078215
[173] Physician follow-up and provider continuity are associated with long-term medication adherence: a study of the dynamics of statin use. — https://doi.org/10.1001/archinte.167.8.847
[178] Assessment and management of statin-associated muscle symptoms (SAMS): A clinical perspective from the National Lipid Association. — https://doi.org/10.1016/j.jacl.2022.09.001
[183] Association of Statin and Antiplatelet Use with Survival in Patients with AAA with and without Concomitant Atherosclerotic Occlusive Disease. — https://doi.org/10.1016/j.avsg.2022.01.014
[198] Early postoperative statin administration does not affect the rate of atrial fibrillation after cardiac surgery. — https://doi.org/10.1093/ejcts/ezz365
[200] Exploring the association between stroke and acute myocardial infarction and statins adherence following a medicines co-payment increase. — https://doi.org/10.1016/j.sapharm.2021.01.011
[203] The impact of pharmacist face-to-face counseling to improve medication adherence among patients initiating statin therapy. — https://doi.org/10.2147/ppa.s29353
[212] Assessing the association between medication adherence, as defined in quality measures, and disease-state control, health care utilization, and costs in a retrospective database analysis of Medicare supplemental beneficiaries using statin medications. — https://doi.org/10.18553/jmcp.2020.26.12.1529
[217] Role of Different Low-Density Lipoprotein-Lowering Medications on Secondary Prevention of Atherosclerotic Cardiovascular Disease in Patients With Diabetes Mellitus. — https://doi.org/10.7759/cureus.40905
[247] Statin utilization and low-density lipoprotein cholesterol in statin-treated patients with atherosclerotic cardiovascular disease: Trends from a community-based health care delivery system, 2002-2016. — https://doi.org/10.1016/j.jacl.2020.03.006
[259] Zero-Dollar Copayment Impact on Adherence Scores for Centers for Medicare and Medicaid Services Star Ratings Generic Medications. — https://doi.org/10.7812/tpp/24.103
[262] Prostate cancer survival among statin users after prostatectomy in a Finnish nationwide cohort. — https://doi.org/10.1002/pros.23768
[267] What is the Statin Possession Ratio Cut-Off Which Identifies Those at Increased Risk Following Acute Coronary Syndrome (ANZACS-QI 68)? — https://doi.org/10.1016/j.hlc.2022.11.012
[279] Effects of Adherence to Statin Therapy on Health Care Outcomes and Utilizations in Taiwan: A Population-Based Study. — https://doi.org/10.1155/2015/149573
[299] Statin adherence and risk of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients: A time-dependent analysis. — https://doi.org/10.1016/j.numecd.2020.07.024
[304] Statin use increased new-onset diabetes in hypercholesterolemic individuals: Data from the Korean National Health Insurance Service-National Health Screening Cohort database (NHIS-HEALS). — https://doi.org/10.1016/j.pcd.2019.08.005
[310] Muscle symptoms in statin users, associations with cytochrome P450, and membrane transporter inhibitor use: a subanalysis of the USAGE study. — https://doi.org/10.1016/j.jacl.2013.10.006
[311] Assessment of effect modification of statins on new-onset diabetes based on various medical backgrounds: a retrospective cohort study. — https://doi.org/10.1186/s40360-019-0314-x
[317] Prostate cancer and PSA among statin users in the Finnish prostate cancer screening trial. — https://doi.org/10.1002/ijc.25165
[318] Prevalence of statin use among high-risk patients in urban and rural Vellore, Tamil Nadu: A population-based cross-sectional study. — https://doi.org/10.4103/ijp.ijp_747_16
[321] Pharmacist-to-prescriber intervention to close therapeutic gaps for statin use in patients with diabetes: A randomized controlled trial. — https://doi.org/10.1016/j.japh.2017.04.009
[323] Older peoples' attitudes regarding polypharmacy, statin use and willingness to have statins deprescribed in Australia. — https://doi.org/10.1007/s11096-015-0147-7
[334] Online health information behaviour and its association with statin adherence in patients with high cardiovascular risk: A prospective cohort study. — https://doi.org/10.1177/20552076241241250
[343] Development of a patient-oriented Hololens application to illustrate the function of medication after myocardial infarction. — https://doi.org/10.1093/ehjdh/ztab053
[347] Predictors of statin adherence, switching, and discontinuation in the USAGE survey: understanding the use of statins in America and gaps in patient education. — https://doi.org/10.1016/j.jacl.2013.03.001
[365] Mortality rate increases steeply with nonadherence to statin therapy in patients with acute coronary syndrome. — https://doi.org/10.1002/clc.22056
[372] Attitudes and actions: A survey to assess statin use among Finnish patients with increased risk for cardiovascular events. — https://doi.org/10.1016/j.jacl.2017.02.013
[389] Age-Related Trajectories of Cardiovascular Risk and Use of Aspirin and Statin Among U.S. Adults Aged 50 or Older, 2011-2018. — https://doi.org/10.1111/jgs.17038
[439] In-hospital statin initiation characteristics and one-year statin adherence rates in patients hospitalised for acute coronary syndrome. — https://doi.org/10.1080/00015385.2020.1794162
[443] Association of Low-Density Lipoprotein Testing After an Atherosclerotic Cardiovascular Event with Subsequent Statin Adherence and Intensification. — https://doi.org/10.1016/j.amjmed.2021.11.011
[450] Inverse Association between Statin Use and Stomach Cancer Incidence in Individuals with Hypercholesterolemia, from the 2002-2015 NHIS-HEALS Data. — https://doi.org/10.3390/ijerph17031054
[458] Statin use and risk of progression to liver cirrhosis in chronic hepatitis B independent of conventional risk factors: A nationwide study. — https://doi.org/10.1002/hep4.2022
[475] Early in-hospital exposure to statins and outcome after intracerebral haemorrhage - Results from the Virtual International Stroke Trials Archive. — https://doi.org/10.1177/2396987319889258
[497] Impact of Appointment-Based Medication Synchronization on Proportion of Days Covered for Chronic Medications. — https://doi.org/10.3390/pharmacy6020044
[528] Long-term statin treatment in children with familial hypercholesterolemia: more insight into tolerability and adherence. — https://doi.org/10.1007/s40272-014-0116-y
[557] Moderate Intensity Exercise Training Improves Skeletal Muscle Performance in Symptomatic and Asymptomatic Statin Users. — https://doi.org/10.1016/j.jacc.2021.08.075
[559] Statin medication use and the risk of biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database. — https://doi.org/10.1002/cncr.25308
[574] Prevalence of potentially severe drug-drug interactions in ambulatory patients with dyslipidaemia receiving HMG-CoA reductase inhibitor therapy. — https://doi.org/10.2165/00002018-200528030-00007
[601] Advantages of statin usage in preventing fractures for men over 50 in the United States: National Health and Nutrition Examination Survey. — https://doi.org/10.1371/journal.pone.0313583
[603] Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort. — https://doi.org/10.1007/s00125-015-3528-5
[671] Statin use is associated with reduced risk of incident intracerebral hemorrhage: A prospective population-based cohort study. — https://doi.org/10.1177/17474930251351103
[677] Association of antecedent statin use on 30-day, 60-day and 90-day mortality among Mississippi Medicaid beneficiaries diagnosed with COVID-19. — https://doi.org/10.1136/bmjopen-2023-076195
[679] Statin use and site-specific risk of colorectal cancer in individuals with hypercholesterolemia from the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS). — https://doi.org/10.1016/j.numecd.2019.04.002
[692] Association between antecedent statin use and severe disease outcomes in COVID-19: A retrospective study with propensity score matching. — https://doi.org/10.1016/j.jacl.2021.03.002
[693] Association between copayment and adherence to statin treatment initiated after coronary heart disease hospitalization: a longitudinal, retrospective, cohort study. — https://doi.org/10.1016/j.clinthera.2007.12.022
[726] Preadmission use of statins and outcomes after hospitalization with pneumonia: population-based cohort study of 29,900 patients. — https://doi.org/10.1001/archinte.168.19.2081
[774] Deintensification or No Statin Treatment Is Associated With Higher Mortality in Patients With Ischemic Stroke or Transient Ischemic Attack. — https://doi.org/10.1161/strokeaha.120.030089
[783] Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population-based cohort study. — https://doi.org/10.1111/bcp.13626
[786] Association between non-adherence to statin and hospitalization for cardiovascular disease and all-cause mortality in a national cohort. — https://doi.org/10.5414/cp202132
[807] Prevalence of Statin Use for Primary Prevention of Atherosclerotic Cardiovascular Disease by Race, Ethnicity, and 10-Year Disease Risk in the US: National Health and Nutrition Examination Surveys, 2013 to March 2020. — https://doi.org/10.1001/jamacardio.2023.0228
[816] The association between antiepileptic drug and HMG-CoA reductase inhibitor co-medication and cholesterol management in patients with epilepsy. — https://doi.org/10.1016/j.eplepsyres.2010.07.021
[817] Association of statin therapy and the risk of atrial fibrillation in patients with a permanent pacemaker. — https://doi.org/10.1002/clc.4960290605
[824] Behavioral Nudges as Patient Decision Support for Medication Adherence: The ENCOURAGE Randomized Controlled Trial. — https://doi.org/10.1016/j.ahj.2021.11.001
[860] Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France. — https://doi.org/10.1093/eurheartj/ehz458
[874] Relation of statin use with non-melanoma skin cancer: prospective results from the Women's Health Initiative. — https://doi.org/10.1038/bjc.2015.376
[875] Synergistic effect of statins and postmenopausal hormone therapy in the prevention of skeletal fractures in elderly women. — https://doi.org/10.1592/phco.30.9.879
[887] Statins reduce new-onset atrial fibrillation in a first-time myocardial infarction population: a nationwide propensity score-matched study. — https://doi.org/10.1177/2047487312462804
[890] Effect of an Automated Patient Dashboard Using Active Choice and Peer Comparison Performance Feedback to Physicians on Statin Prescribing: The PRESCRIBE Cluster Randomized Clinical Trial. — https://doi.org/10.1001/jamanetworkopen.2018.0818
[895] Evaluating the Impact of Common Non-Oncologic Medication Use During Radiotherapy in Patients with High-Risk Prostate Cancer. — https://doi.org/10.3390/curroncol32060353
[900] Association of Statins With Functional Outcome and 30-Day Mortality in Patients With Intracerebral Hemorrhage. — https://doi.org/10.7759/cureus.14421
[903] Observing versus Predicting: Initial Patterns of Filling Predict Long-Term Adherence More Accurately Than High-Dimensional Modeling Techniques. — https://doi.org/10.1111/1475-6773.12310
[917] Statin Use Ameliorates Survival in Oral Squamous Cell Carcinoma-Data from a Population-Based Cohort Study Applying Propensity Score Matching. — https://doi.org/10.3390/biomedicines11020369
[930] The effect of statins on muscle symptoms in primary care: the StatinWISE series of 200 N-of-1 RCTs. — https://doi.org/10.3310/hta25160
[972] A Propensity Score Matched Approach to Assess the Associations of Commonly Prescribed Medications with Fall Risk in a Large Harmonized Cohort of Older Ambulatory Persons. — https://doi.org/10.1007/s40266-021-00876-0
[981] Low adherence to statin treatment during the 1st year after an acute myocardial infarction is associated with increased 2nd-year mortality risk-an inverse probability of treatment weighted study on 54 872 patients. — https://doi.org/10.1093/ehjcvp/pvaa010
[989] Effect of Preloading With High Dose of Rosuvastatin on Serum Levels of Inflammatory Markers After Percutaneous Coronary Intervention. — https://doi.org/10.25270/jic/20.00064
[1050] High exposure to statins decrease the risk of new-onset dementia: A nationwide population-based longitudinal cohort study. — https://doi.org/10.1097/md.0000000000016931
[1074] Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. — https://doi.org/10.1002/mds.27006
[1076] Use of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Statin-Associated Immune-Mediated Necrotizing Myopathy: A Case Series. — https://doi.org/10.1002/art.40919
[1079] Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study. — https://doi.org/10.1186/s13195-023-01360-0
[1081] Providing systematic detailed information on medication upon hospital discharge as an important step towards improved transitional care. — https://doi.org/10.1111/jcpt.12140
[1085] Low-density lipoprotein cholesterol management after acute coronary syndrome in Aotearoa New Zealand: opportunities for improvement (ANZACS-QI 81). — https://doi.org/10.26635/6965.6818
[1091] A pharmacovigilance study of chronic kidney disease in diabetes mellitus patients with statin treatment by using the US Food and Drug Administration adverse event reporting system. — https://doi.org/10.3389/fphar.2024.1363501
[1105] Effect of a pharmacist-led intervention on adherence among patients with a first-time prescription for a cardiovascular medicine: a randomized controlled trial in Norwegian pharmacies. — https://doi.org/10.1111/ijpp.12598
[1110] Factors associated with non-proliferative diabetic retinopathy in patients with type 1 and type 2 diabetes: the Japan Diabetes Complication and its Prevention prospective study (JDCP study 4). — https://doi.org/10.1007/s13340-018-0357-z
[1117] Do immigrants from Turkey, Pakistan and Ex-Yugoslavia with newly diagnosed type 2 diabetes initiate recommended statin therapy to the same extent as Danish-born residents? A nationwide register study. — https://doi.org/10.1007/s00228-012-1306-6
[1139] Randomized Trial of a Pharmacist-Delivered Intervention for Improving Lipid-Lowering Medication Adherence among Patients with Coronary Heart Disease. — https://doi.org/10.1155/2010/383281
[1147] Adherence to and beliefs in lipid-lowering medical treatments: a structural equation modeling approach including the necessity-concern framework. — https://doi.org/10.1016/j.pec.2012.11.001
[1156] Prescribing patterns and adherence to medication among South-Asian, Chinese and white people with type 2 diabetes mellitus: a population-based cohort study. — https://doi.org/10.1111/dme.12559
[1173] Association between statin use and the incidence of atrial fibrillation following hospitalization for coronary artery disease. — https://doi.org/10.1016/j.amjcard.2010.01.341
[1205] Examining the association between medication adherence trajectories and disease-specific clinical outcomes: An analysis focusing on the drug classes included in Part D quality bonus payments. — https://doi.org/10.18553/jmcp.2025.31.11.1177
[1207] Combination therapy with moderate-intensity atorvastatin and ezetimibe vs. high-intensity atorvastatin monotherapy in patients treated with percutaneous coronary intervention in practice: assessing RACING generalizability. — https://doi.org/10.1093/ehjcvp/pvad083
[1209] ACE inhibitors, statins and thiazides: no association with change in grip strength among community dwelling older men and women from the Hertfordshire Cohort Study. — https://doi.org/10.1093/ageing/afu008
[1228] An Outpatient Pharmacist Strategy Improves Guideline Adherent Medication Prescribing in Patients with Vascular Disease. — https://doi.org/10.1016/j.ejvs.2025.07.014
[1231] Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention : A Randomized Trial. — https://doi.org/10.7326/annals-24-00944
[1263] High-potency statins but not all statins decrease the risk of new-onset osteoporotic fractures: a nationwide population-based longitudinal cohort study. — https://doi.org/10.2147/clep.s145311
[1273] The Association of Metformin, Other Antidiabetic Medications and Statins on the Prognosis of Rectal Cancer in Patients with Type 2 Diabetes: A Retrospective Cohort Study. — https://doi.org/10.3390/biom12091301
[1300] Is the KOS-Zawał coordinated care program effective in reducing long-term cardiovascular risk in coronary artery disease patients in Poland? Insights from analysis of statin persistence in a nationwide cohort. — https://doi.org/10.33963/v.phj.101307
[1304] The prevalence, low-density lipoprotein cholesterol levels, and treatment of patients at very high risk of cardiovascular events in the United Kingdom: a cross-sectional study. — https://doi.org/10.1080/03007995.2018.1463211
[1305] Anti-inflammatory treatment and risk of depression in 91,842 patients with acute coronary syndrome and 91,860 individuals without acute coronary syndrome in Denmark. — https://doi.org/10.1016/j.ijcard.2017.05.105
[1317] Do statins interfere with lifestyle intervention in the prevention of diabetes in primary healthcare? One-year follow-up of the FIN-D2D project. — https://doi.org/10.1136/bmjopen-2012-001472
[1318] Effects of Aspirin, Nonsteroidal Anti-inflammatory Drugs, Statin, and COX2 Inhibitor on the Developments of Urological Malignancies: A Population-Based Study with 10-Year Follow-up Data in Korea. — https://doi.org/10.4143/crt.2017.248
[1342] Preoperative high-dose atorvastatin for prevention of atrial fibrillation after cardiac surgery: a randomized controlled trial. — https://doi.org/10.1016/j.jtcvs.2010.06.006
[1396] Cardiovascular medication adherence testing in patients living with HIV: A single-centre observational study. — https://doi.org/10.1111/hiv.13715
[1397] Baseline morbidity and chronic medications as determinants of sepsis outcomes: focus on statins, corticosteroids, and NSAIDs in a population-based cohort of 59,578 patients. — https://doi.org/10.3389/fphar.2025.1727662
[1491] Impact of Antihypertensive and Lipid-Lowering Agents on Hepatocellular Carcinoma Risk in Patients with Fatty Liver Disease and Diabetes. — https://doi.org/10.1007/s10620-025-08935-x
[1511] Rosuvastatin improves endothelial function in patients with inflammatory joint diseases, longitudinal associations with atherosclerosis and arteriosclerosis: results from the RORA-AS statin intervention study. — https://doi.org/10.1186/s13075-015-0795-y
[1527] Individualized Risk Communication and Outreach for Primary Cardiovascular Disease Prevention in Community Health Centers: Randomized Trial. — https://doi.org/10.1161/circoutcomes.115.001723
[1549] Age and gender differences in medical adherence after myocardial infarction: Women do not receive optimal treatment - The Netherlands claims database. — https://doi.org/10.1177/2047487317744363
[1560] Cardiovascular Medication Use and Long-Term Outcomes of First Nations and Non-First Nations Patients Following Diagnostic Angiography: A Retrospective Cohort Study. — https://doi.org/10.1161/jaha.119.012040
[1573] Sex disparities in medication prescribing amongst patients with type 2 diabetes mellitus managed in primary care. — https://doi.org/10.1111/dme.14987
[1594] Gender Differences in Healthy Lifestyle Adherence Following Percutaneous Coronary Intervention for Coronary Artery Disease. — https://doi.org/10.1016/j.hlc.2020.06.024
[1633] Implementing simple algorithms to improve glucose and lipid management in people with diabetes and acute coronary syndrome. — https://doi.org/10.1111/dme.14095
[1634] An Intervention to Improve Medication Adherence in People With Heart Disease (Text4HeartII): Randomized Controlled Trial. — https://doi.org/10.2196/24952
[1638] Level and variation on quality of care in China: a cross-sectional study for the acute myocardial infarction patients in tertiary hospitals in Beijing. — https://doi.org/10.1186/s12913-019-3872-0
[1639] Adherence to quality of care measurements among 58,182 patients with new onset diabetes and its association with mortality. — https://doi.org/10.1371/journal.pone.0208539
[1648] The Effects of 3-Month Rosuvastatin Adjuvant Therapy on Post Thrombotic Syndrome following Deep Vein Thrombosis; a Randomized Clinical Trial. — https://doi.org/10.22037/aaem.v11i1.1972
[1657] Investigating the ability to adhere to cardiometabolic medications with different properties: a retrospective cohort study of >500 000 patients in the USA. — https://doi.org/10.1136/bmjopen-2023-075840
[1662] Factors Affecting Patency following Successful Percutaneous Intervention for Dysfunctional Hemodialysis Vascular Access. — https://doi.org/10.1016/j.avsg.2017.08.003
[1749] Cholesterol management in US adults with ASCVD in the Family Heart Database® during 2022-23: Current state of care and opportunities for improvement. — https://doi.org/10.1016/j.ajpc.2025.101354
[1762] Population-based study of statins, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors on pneumonia-related outcomes. — https://doi.org/10.1093/cid/cis733
[1772] Informed shared decision-making programme for patients with type 2 diabetes in primary care: cluster randomised controlled trial. — https://doi.org/10.1136/bmjopen-2018-024004
[1798] Identification of Gender Differences in Acute Myocardial Infarction Presentation and Management at Aga Khan University Hospital-Pakistan: Natural Language Processing Application in a Dataset of Patients With Cardiovascular Disease. — https://doi.org/10.2196/42774
[1837] Optimal medical management in patients undergoing peripheral vascular interventions for chronic limb-threatening ischemia is associated with improved outcomes. — https://doi.org/10.1016/j.jvs.2023.04.025
[1841] Incidence and risk factors associated with index hospitalization leg ischemia following endovascular abdominal aortic aneurysm repair. — https://doi.org/10.1016/j.jvs.2025.09.023
[1848] Evaluating Medication Day-Supply for Improving Adherence and Clinical Biomarkers of Hemoglobin A1c, Blood Pressure, and Low-Density Lipoprotein. — https://doi.org/10.1177/08971900221129424
[1866] Statins Reduce the Risk of Cirrhosis and Its Decompensation in Chronic Hepatitis B Patients: A Nationwide Cohort Study. — https://doi.org/10.1038/ajg.2016.179
[1911] Impact of metformin, statins, and beta blockers on survival in patients with primary ovarian cancer: combined analysis of four prospective trials of AGO-OVAR and ENGOT/GCIG collaborators. — https://doi.org/10.1136/ijgc-2024-005663
[1914] Screening for Subclinical Atherosclerosis in Patients with Familial Hypercholesterolemia: Insights and Implications. — https://doi.org/10.3390/jcm14020656
[1916] Efficacy of a WeChat-based intervention for adherence to secondary prevention therapies in patients undergoing coronary artery bypass graft in China: A randomized controlled trial. — https://doi.org/10.1177/1357633x20960639
[1924] Long-term cardiac outcome in high-risk patients undergoing elective endovascular or open infrarenal abdominal aortic aneurysm repair. — https://doi.org/10.1016/j.ejvs.2008.09.008
[1935] Anti-inflammatory treatment and risk for depression after first-time stroke in a cohort of 147 487 Danish patients. — https://doi.org/10.1503/jpn160244
[1952] Achievement of low-density lipoprotein cholesterol targets in Chinese patients with atherosclerotic cardiovascular disease after receiving statins and ezetimibe. — https://doi.org/10.3389/fcvm.2022.988576
[2087] Lipid Profile in Indian Patients With Type 2 Diabetes: The Scope for Atherosclerotic Cardiovascular Disease Risk Reduction. — https://doi.org/10.2337/ds19-0046
[2104] Expansion of small-diameter abdominal aortic aneurysms is not reflected by the release of inflammatory mediators IL-6, MMP-9 and CRP in plasma. — https://doi.org/10.1016/j.ejvs.2008.11.027
[2121] Patient characteristics, treatment patterns, and adherence to lipid-lowering therapies following an acute coronary syndrome. — https://doi.org/10.31083/j.rcm.2020.04.189
[2131] Processes of Care Associated With Risk of Mortality and Recurrent Stroke Among Patients With Transient Ischemic Attack and Nonsevere Ischemic Stroke. — https://doi.org/10.1001/jamanetworkopen.2019.6716
[2132] Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016. — https://doi.org/10.1001/jamaneurol.2020.1512
[2136] Editor's Choice - Impact of Comorbidity, Medication, and Gender on Amputation Rate Following Revascularisation for Chronic Limb Threatening Ischaemia. — https://doi.org/10.1016/j.ejvs.2018.06.003
[2209] High-dose atorvastatin reloading before percutaneous coronary intervention increased circulating endothelial progenitor cells and reduced inflammatory cytokine expression during the perioperative period. — https://doi.org/10.1177/1074248413513500
[2260] The long-term effect of statins on the risk of new-onset diabetes mellitus in elderly Taiwanese patients with hypertension and dyslipidaemia: a retrospective longitudinal cohort study. — https://doi.org/10.2165/11597250-000000000-00000
[2313] Improved treatment of coronary heart disease by implementation of a Cardiac Hospitalization Atherosclerosis Management Program (CHAMP). — https://doi.org/10.1016/s0002-9149(00)01519-8
[2348] Influence of preoperative lipid-lowering therapy on postoperative outcome in patients undergoing coronary artery bypass grafting. — https://doi.org/10.1016/j.amjcard.2006.10.036
[2364] Sustained Improvement of Arterial Stiffness and Blood Pressure after Long-Term Rosuvastatin Treatment in Patients with Inflammatory Joint Diseases: Results from the RORA-AS Study. — https://doi.org/10.1371/journal.pone.0153440
[2429] Underutilization of medical management of peripheral artery disease among patients with claudication undergoing lower extremity bypass. — https://doi.org/10.1016/j.jvs.2022.05.016
[2493] Effectiveness of a primary care-based integrated mobile health intervention for stroke management in rural China (SINEMA): A cluster-randomized controlled trial. — https://doi.org/10.1371/journal.pmed.1003582
[2525] Lipid-Lowering Medications Are Associated with Lower Risk of Retinopathy and Ophthalmic Interventions among United States Patients with Diabetes. — https://doi.org/10.1016/j.ajo.2019.05.029
[2537] Differential Adherence to Free and Single-Pill Combination of Rosuvastatin/Ezetimibe: Findings from a Real-World Analysis in Italy. — https://doi.org/10.1007/s12325-024-02916-8
