Abdominal aortic aneurysm is becoming less common in routine population screening, but prevalence remains sharply concentrated in older male smokers, first-degree relatives, and patients with vascular or cardiopulmonary disease. This review maps where AAA is now rare, where it is still unexpectedly frequent, and why future screening may need to become more targeted than universal.
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Abstract: To synthesize current evidence on the prevalence of abdominal aortic aneurysm (AAA) across diverse populations, clinical settings, and risk groups based on recent cohort and cross-sectional studies. The review utilises 419 original studies with 6230192 total participants (topic deduplicated ΣN). The mapped evidence indicates that contemporary AAA prevalence in screened 65-year-old men clusters around a median of 1.5% (range 1.32%–2.6%), with consistently lower rates in women (median 0.5%, range 0%–1.3%) and a clear declining trend over recent decades, exemplified by reductions from 5.0% in 1991 to 1.3% in 2015 in long-running programmes. Across the topic synthesis, prevalence was strongly modulated by smoking, advancing age, male sex, and family history, with brothers of affected individuals reaching lifetime estimates as high as 32% and peripheral artery disease cohorts approaching 13%. Recurrent signals also support elevated yields in chronic obstructive pulmonary disease, coronary artery disease, inguinal hernia, and cerebrovascular disease populations, alongside an apparently inverse association with diabetes mellitus that warrants mechanistic exploration. The evidence map further highlights substantial geographic and ethnic heterogeneity, with lower prevalence in Asian populations and notably higher burden in New Zealand Māori, suggesting that universal one-size-fits-all screening thresholds may be suboptimal. Clinically, these signals support a shift toward risk-factor-targeted and opportunistic screening embedded within cardiology, primary care, and incidental imaging workflows rather than reliance on age- and sex-based invitation alone. Future research should prioritise prospective validation of risk-stratified screening models incorporating smoking, family history, comorbidity, and body-size-adjusted aortic indices, particularly in women and underrepresented non-Western populations, to refine equitable and cost-effective surveillance strategies in an era of declining background prevalence.
Final search date and database lock: 2026-05-01 20:57:25 CEST
Plan: Pro (expanded craft tokens; source: PubMed)
Source: PubMed
Total Abstracts/Papers: 1013
Downloaded Abstracts/Papers: 1013
Included original and non-original Abstracts/Papers (all): 480
Included original Abstracts/Papers (Vote counting by direction of effect): 419
Reference Index (links used in paper): 167
Total participants (topic deduplicated ΣN): 6230192
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