Aortic Dissection Prevalence: Scoping Review with ☸️SAIMSARA.

Name: SAIMSARA Evidence Object vascular::AORTIC_DISSECTION_PREVALENCE_PM
Creator: SAIMSARA
License: https://saimsara.com/license/

SAIMSARA

doi:10.62487/saimsara9f77c469

SAIMSARA Journal

Machine-Readable Science • ISSN 3054-3991

Aortic Dissection Prevalence: Scoping Review with ☸️SAIMSARA.

Cardiac & Vascular Health

Issue 1, Volume 1, 2026

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DOI: 10.62487/saimsara9f77c469

Editorial note

• Last update: 2026-04-28 08:12:01

What is this paper about

Aortic dissection prevalence is not one number — it changes dramatically by clinical setting, genetics, anatomy, sleep apnea, mental health burden, and referral selection. This review is worth reading because it maps where “rare disease” thinking fails and where targeted screening may reveal preventable high-risk phenotypes.

Human-verified editorial review Verified by World ID proof-of-human. This editorial layer was submitted from a SAIMSARA account verified as a unique human.

Abstract: The aim of this review is to synthesize contemporary evidence regarding the prevalence of aortic dissection across diverse clinical settings and populations, while identifying key anatomical, genetic, and comorbid predictors associated with the condition. The review utilises 145 references. The mapped evidence indicates that aortic dissection prevalence is highly context-dependent, ranging from 0.3% in undifferentiated emergency chest-pain presentations to 10–25% in Marfan syndrome and up to 88.7% in selectively transferred suspected acute aortic syndrome cohorts. Recurrent signals across topics highlight a strikingly high burden of obstructive sleep apnea (61%–66.2%), post-traumatic stress disorder (21.4%–31.5%), and bovine aortic arch variation in dissection and broader thoracic aortopathy cohorts (15.6%–31.1%), alongside a consistent inverse association with diabetes mellitus. Heritable contribution emerged as a dominant theme, with familial factors accounting for an estimated 27.9% to 57% of liability and pathogenic variant yields reaching 51.5% in selected thoracic aortic aneurysm and dissection cohorts. Clinically, these patterns support integrating genetic evaluation, sleep assessment, and structured psychological screening into longitudinal management of dissection survivors, while flagging anatomical variants on routine imaging. The evidence remains heterogeneous in denominators and dominated by retrospective single-center cohorts, which limits certainty around true population-level burden. Future research should prioritize prospective multicenter registries with standardized prevalence reporting to clarify the diabetes paradox, the mechanistic role of obstructive sleep apnea in false-lumen behavior, and sex- and age-specific phenotypes that currently drive much of the observed heterogeneity.

Keywords: Aortic dissection prevalence; Stanford Type A; Stanford Type B; Genetic heritability; Obstructive sleep apnea; Malperfusion syndrome; Aortic arch variants; Intracranial aneurysms; Acute aortic syndrome; Thoracic aortic aneurysm

Review Stats

Final search date and database lock: 2026-04-26 22:40:44 CEST
Plan: Pro (expanded craft tokens; source: PubMed)
Source: PubMed
Total Abstracts/Papers: 670
Downloaded Abstracts/Papers: 670
Included original and non-original Abstracts/Papers (all): 423
Included original Abstracts/Papers (Vote counting by direction of effect): 366
Reference Index (links used in paper): 145
Total participants (topic deduplicated ΣN): 3728233

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Reference Index (145)

[1] Clinical Examination for Acute Aortic Dissection: A Systematic Review and Meta-analysis. — https://doi.org/10.1111/acem.13360
[2] A systematic review and meta-analysis of isolated abdominal aortic dissection. — https://doi.org/10.1016/j.jvs.2019.04.467
[3] Association of Ductus Diverticulum and Acute Type B Aortic Dissection. — https://doi.org/10.1016/j.acra.2023.01.015
[4] Negative Association of Diabetes With Thoracic Aortic Dissection and Aneurysm. — https://doi.org/10.1177/0003319716647626
[5] Association of Mental Health Disorders and Aortic Dissection. — https://doi.org/10.1016/j.avsg.2021.05.054
[6] Sex Differences in Thoracic Aortic Disease and Dissection: JACC Review Topic of the Week. — https://doi.org/10.1016/j.jacc.2023.05.067
[7] Clinical, diagnostic, and management perspectives of aortic dissection. — https://doi.org/10.1378/chest.122.1.311
[8] Prevalence of Intracranial Aneurysms in Patients with Aortic Dissection. — https://doi.org/10.3174/ajnr.a5359

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