Erectile Dysfunction as a Cardiovascular Risk Marker: Scoping Review with ☸️SAIMSARA.

Name: SAIMSARA Evidence Object vascular::CARDIOVASCULAR_ERECTILE_DYSFUNCTION_PM
Creator: SAIMSARA
License: https://saimsara.com/license/

SAIMSARA

doi:10.62487/saimsarad8b0bda9

SAIMSARA Journal

Machine-Readable Science • ISSN 3054-3991

Erectile Dysfunction as a Cardiovascular Risk Marker: Scoping Review with ☸️SAIMSARA.

Cardiac & Vascular Health

Issue 1, Volume 1, 2026

Chat with this issue

DOI: 10.62487/saimsarad8b0bda9

Editorial note

• Last update: 2026-05-30 15:34:03

What is this paper about

Erectile dysfunction is often treated as a private urological complaint, but this review shows why it may be an early vascular warning signal. The full read maps more than 800 original studies to clarify how vasculogenic ED overlaps with cardiovascular risk, subclinical atherosclerosis, diabetes, hypertension, PDE5 inhibitor safety, and the need for integrated urology–cardiology care.

Human-verified editorial review Verified by World ID proof-of-human. This editorial layer was submitted from a SAIMSARA account verified as a unique human.

Abstract: To synthesize original human and animal studies relevant to “cardiovascular erectile dysfunction,” with emphasis on ED as a cardiovascular risk marker, predictor, mechanistic phenotype, screening opportunity, and treatment-relevant clinical condition. The review uses 211 references and builds its evidence map from 886 original studies with 53214933 total participants/sample observations (topic-deduplicated ΣN). The dominant signal across this scoping review is that erectile dysfunction behaves as a vascular sentinel of systemic cardiovascular disease, with ED severity tracking future events, mortality, and subclinical vascular abnormalities rather than representing an isolated urological condition. This pattern recurs across endothelial, arterial-stiffness, coronary-flow, and imaging-based studies, and is reinforced by penile Doppler findings linking cavernous artery abnormalities to roughly threefold higher MACE risk. PDE5 inhibitors appear generally tolerated in stable cardiovascular settings, although nitrate co-use remains a clinically critical safety boundary. Taken together, the evidence supports treating ED as an actionable trigger for cardiovascular risk assessment and integrated urology–cardiology care, while recognizing that mapped associations do not establish causality. Future prospective trials should test whether ED-initiated cardiovascular screening pathways measurably reduce events compared with usual care.

Keywords: Erectile dysfunction; Cardiovascular disease; Cardiovascular risk; Phosphodiesterase inhibitors; Myocardial infarction; Atherosclerosis; Endothelial dysfunction; Metabolic syndrome; Hypertension; Cardiac dysfunction

Review Stats

Final search date and database lock: 2026-05-21 20:58:13 CEST
Plan: Pro (expanded craft tokens; source: PubMed)
Source: PubMed
Total Abstracts/Papers: 2124
Downloaded Abstracts/Papers: 2124
Included original and non-original Abstracts/Papers (all): 1120
Included original Abstracts/Papers (Vote counting by direction of effect): 886
Reference Index (links used in paper): 211
Total participants/sample observations (topic deduplicated ΣN): 53214933

Get access to the full paper

Unlock the full evidence map

Full paper access includes the complete human-readable review, figures, reference index, PDF export, and machine-readable Evidence JSON download.
Evidence JSON can also be purchased separately if you only need the LLM-ready object for agent, AI, or RAG workflows.
Institutional or library access? Sign in with your institution email to open all available SAIMSARA papers under your institution access arrangement.
Need a SAIMSARA review on your own topic? ☸️Request.

Reference Index (211)

[1] Benefits of Tadalafil and Sildenafil on Mortality, Cardiovascular Disease, and Dementia. — https://doi.org/10.1016/j.amjmed.2024.10.039
[2] Reassessing cardiovascular risk stratification in men with erectile dysfunction. — https://doi.org/10.4081/aiua.2024.12427
[3] Education degree predicts cardiovascular outcomes in men suffering from erectile dysfunction. — https://doi.org/10.1111/andr.13389
[4] Cardiovascular drugs and erectile dysfunction - a symmetry analysis. — https://doi.org/10.1111/bcp.12696
[5] Erectile dysfunction and subsequent cardiovascular disease. — https://doi.org/10.1001/jama.294.23.2996
[6] Erectile dysfunction and risk of cardiovascular and all-cause mortality in the general population: a meta-analysis of cohort studies. — https://doi.org/10.1007/s00345-018-2318-3
[7] Erectile dysfunction and cardiovascular disease. — https://doi.org/10.1016/j.aju.2013.03.003
[8] Men with erectile dysfunction (ED) should be screened for cardiovascular risk factors - Cost-benefit considerations in Swiss men. — https://doi.org/10.1024/0301-1526/a001105

Unlock the full paper to view the complete Reference Index.