Machine-Readable Science • ISSN 3054-3991

Diabetic Foot: Systematic Review with ☸️SAIMSARA.

Name: SAIMSARA Evidence Object vascular::DIABETIC_FOOT_PM
Creator: SAIMSARA
License: https://saimsara.com/license/

Cardiac & Vascular Health

Issue 1, Volume 1, 2026

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DOI: 10.62487/saimsarab8c0aed0

Editorial note

• Last update: 2026-03-26 19:56:44

What is this paper about

Diabetic foot is not just a wound problem but a high-stakes collision of neuropathy, ischemia, infection, and delayed care, with a median major amputation rate of 10.3% across the mapped evidence. This review shows where the strongest signals truly are: why multidisciplinary care can cut major amputations by up to 80%, which risk factors matter most, and which emerging diagnostics and regenerative therapies may actually change outcomes.

Abstract: To systematically review and synthesize the available evidence addressing: diabetic foot. The review utilises 4398 original studies with 9269773 total participants (naïve ΣN). The findings underscore the severe burden of this complication, evidenced by high rates of ulceration, infection, and a median major amputation rate of 10.3%. Key risk factors, including neuropathy, peripheral arterial disease, and poor glycemic control, are consistently identified across diverse populations. A critical and recurring theme is the profound impact of multidisciplinary care, which has been shown to reduce major amputations by up to 80%. Despite this, significant gaps persist in patient self-care practices and provider adherence to screening guidelines, representing a major barrier to prevention. The field is rapidly advancing with novel biomarkers, advanced imaging, AI-driven diagnostics, and regenerative therapies showing promise, though many require further validation. A primary limitation of the current literature is the heterogeneity of study designs and reporting, which hinders direct comparison and meta-analysis. Therefore, a crucial future direction is the establishment of standardized, integrated care pathways that incorporate evidence-based screening, patient education, and multidisciplinary management to reduce the devastating impact of diabetic foot disease.

Keywords: Diabetic Foot Ulcer; Wound Healing; Amputation; Patient Education; Self-Care; Neuropathy; Multidisciplinary Care; Risk Assessment; Offloading; Diabetic Retinopathy

Review Stats

Generated: 2026-03-04 22:44:29 CET
Plan: Pro (expanded craft tokens; source: PubMed)
Source: PubMed
Scope: Titles/Abstracts (tiab)
Keyword Gate: Fuzzy (≥60% of required terms, minimum 2 terms matched in title/abstract)
Total Abstracts/Papers: 19378
Downloaded Abstracts/Papers: 10000
Included Abstracts/Papers (all): 4977
Included original Abstracts/Papers (Vote counting based on direction of effect): 4398
Reference Index (links used in paper): 331
Total study participants (naïve ΣN): 9269773

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Reference Index (331)

[1] [Diabetic foot syndrome-Part 1 : Definition, pathophysiology, diagnostics and classification]. — https://doi.org/10.1007/s00104-020-01301-9
[2] The microbiology of diabetic foot infections: a meta-analysis. — https://doi.org/10.1186/s12879-021-06516-7
[3] Omentin-1 and diabetic foot. — https://doi.org/10.1177/15347346211069813
[4] Diabetic foot problem in Nepal. — https://doi.org/10.3389/fendo.2023.1277940
[5] Diabetic Foot Complications: A Retrospective Cohort Study. — https://doi.org/10.3390/ijerph20010187
[6] Diabetic foot care behavior and self-efficacy levels in individuals with diabetic foot ulcers in Turkey. — https://doi.org/10.1016/j.jtv.2025.100885
[7] Diabetic foot infection treatment and care. — https://doi.org/10.1111/iwj.12277
[8] Diabetic foot workshop: A strategy for improving the knowledge of diabetic foot care providers. — https://doi.org/10.1016/j.dsx.2022.102543

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