SAIMSARA Journal

Machine Generated Science • ISSN 3054-3991

Diabetic Foot: Systematic Review with ☸️SAIMSARA.

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Vascular Health

Issue 1, Volume 1, 2026

Editorial note
• Last update: 2026-03-26 19:56:44
What is this paper about
Diabetic foot is not just a wound problem but a high-stakes collision of neuropathy, ischemia, infection, and delayed care, with a median major amputation rate of 10.3% across the mapped evidence. This review shows where the strongest signals truly are: why multidisciplinary care can cut major amputations by up to 80%, which risk factors matter most, and which emerging diagnostics and regenerative therapies may actually change outcomes.


DOI: 10.62487/saimsarab8c0aed0


Abstract: To systematically review and synthesize the available evidence addressing: diabetic foot. The review utilises 4398 original studies with 9269773 total participants (naïve ΣN). The findings underscore the severe burden of this complication, evidenced by high rates of ulceration, infection, and a median major amputation rate of 10.3%. Key risk factors, including neuropathy, peripheral arterial disease, and poor glycemic control, are consistently identified across diverse populations. A critical and recurring theme is the profound impact of multidisciplinary care, which has been shown to reduce major amputations by up to 80%. Despite this, significant gaps persist in patient self-care practices and provider adherence to screening guidelines, representing a major barrier to prevention. The field is rapidly advancing with novel biomarkers, advanced imaging, AI-driven diagnostics, and regenerative therapies showing promise, though many require further validation. A primary limitation of the current literature is the heterogeneity of study designs and reporting, which hinders direct comparison and meta-analysis. Therefore, a crucial future direction is the establishment of standardized, integrated care pathways that incorporate evidence-based screening, patient education, and multidisciplinary management to reduce the devastating impact of diabetic foot disease.

Keywords: Diabetic Foot Ulcer; Wound Healing; Amputation; Patient Education; Self-Care; Neuropathy; Multidisciplinary Care; Risk Assessment; Offloading; Diabetic Retinopathy

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