SAIMSARA Journal

Machine Generated Science • ISSN 3054-3991

Hantavirus Infection: Scoping Review with ☸️SAIMSARA.

Infectious Diseases

Infectious Diseases

Issue 7, Volume 1, 2026

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DOI: 10.62487/saimsara12cb6553

Editorial note
• Last update: 2026-05-11 12:20:09
What is this paper about
Hantavirus infection is not just a rare rodent-borne fever: this evidence map shows it as a multisystem vascular infection driven by ecology, endothelial dysfunction, thrombocytopenia, and renal or cardiopulmonary injury. The full SAIMSARA paper and machine-readable JSON provide structured, reference-linked evidence across 1,084 original studies, covering diagnosis, exposure risk, Andes-virus transmission, severity markers, One Health surveillance, and the still-unproven therapeutic frontier.
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Evidence preview · Did you know?
Realistic medical scene suggesting severe hantavirus cardiopulmonary illness and emergency clinical care.

A rodent-borne infection can become fatal fast

Did you know? New World hantavirus cardiopulmonary disease showed reported mortality of 34.4% in pediatric HCPS and 55.6% in French Guiana.

This is why hantavirus is not just a rare fever, but a high-stakes vascular leakage syndrome requiring early recognition.

Realistic indoor rodent exposure scene showing domestic and peridomestic hantavirus risk without text.

The risk can enter ordinary homes

Did you know? Seoul virus exposure was reported in 34.1% of pet fancy rat owners versus 3.3% of controls in England.

The evidence map shows that hantavirus risk is not limited to wilderness outbreaks; urban and domestic rat exposure also matters.

Realistic outbreak-control scene with clinicians and public-health workers responding to suspected hantavirus transmission.

One hantavirus can change outbreak control

Did you know? Andes virus is the key exception where person-to-person spread is supported, and isolation/quarantine reduced R below 1 in one Argentine outbreak.

This makes species-aware diagnosis, exposure history, and public-health containment central to the full evidence story.

Swipe sideways on mobile · full evidence map opens after unlock

Abstract: To synthesize original-study evidence on hantavirus infection, emphasizing clinical presentation, diagnosis, epidemiology, transmission ecology, pathophysiology, complications, risk factors, prognostic markers, and emerging therapeutic or preventive strategies. The review uses 370 references and builds its evidence map from 1,084 original studies with 612,269 total participants (topic-deduplicated ΣN). Across the mapped evidence, hantavirus infection emerges most consistently as an ecologically driven, multisystem vascular disease in which immune-mediated endothelial dysfunction, thrombocytopenia, and renal or cardiopulmonary injury together shape clinical severity. The data support approaching suspected cases through syndromic recognition of fever with thrombocytopenia and AKI, structured exposure assessment, and species-aware diagnostic confirmation combining serology with molecular testing. Therapeutic evidence in humans remains limited, with neither ribavirin nor high-dose methylprednisolone showing clear benefit, while preclinical work on neutralizing antibodies, entry inhibitors, and vaccine platforms is advancing but unproven clinically. A practical implication is that integrated One Health surveillance and early severity-marker monitoring could improve recognition in endemic and emerging settings. The dominant remaining uncertainty—how to translate mechanistic and animal-model insights into effective human-specific therapeutics—should be addressed through adaptive platform trials using standardized, species-specific case definitions.

Keywords: Hantavirus infection; Hemorrhagic fever; Puumala virus; Hantaan virus; Andes virus; Rodent reservoirs; Viral seroprevalence; Renal disease; Immune response; Viral transmission

Review Stats

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The full evidence review, including the Introduction, Methods, Results, Discussion, Conclusion, figures, and complete reference index, opens after purchase or sign-in. The Evidence Object JSON is a separate machine-readable evidence product: a concentrated synthesis of results, topic-level evidence, and discussion across original and non-original studies. It can be directly input into your LLM, agent, or RAG workflow.

Reference Index (370)
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