Peripheral Artery Disease and Gender: Systematic Review with ☸️SAIMSARA.

Name: SAIMSARA Evidence Object vascular::PAD_GENDER_SS
Creator: SAIMSARA
License: https://saimsara.com/license/

SAIMSARA

doi:10.62487/saimsarad77d7bd0

SAIMSARA Journal

Machine-Readable Science • ISSN 3054-3991

Peripheral Artery Disease and Gender: Systematic Review with ☸️SAIMSARA.

Cardiac & Vascular Health

Issue 1, Volume 1, 2026

Chat with this issue

DOI: 10.62487/saimsarad77d7bd0

Editorial note

• Last update: 2026-03-28 10:17:06

What is this paper about

This paper shows that PAD does not affect women and men in the same way: women are often treated less aggressively and face more perioperative complications, while men more often carry the burden of amputation, mortality, and severe limb outcomes. The full paper is worth reading because it makes clear where the true gender gap lies in PAD—not just in prevalence, but in diagnosis, treatment, and what happens after intervention.

Abstract: This paper aims to synthesize current evidence regarding the association between gender and peripheral artery disease (PAD), specifically evaluating differences in prevalence, risk factor profiles, clinical management, procedural outcomes, and limb-related complications across diverse patient populations. The review utilises 209 original studies with 3925814 total participants (ΣN). The evidence suggests a consistent gender-based treatment and outcomes gap: women are less likely to receive guideline-directed pharmacotherapy and vascular specialist care, and often experience higher perioperative morbidity, bleeding, stroke, and repeat revascularization, whereas men more often show greater hospitalized burden, PAD-related mortality, and amputation risk in PAD/diabetes cohorts. Findings on prevalence remain context-dependent, with some screening studies indicating higher ABI-defined PAD prevalence in women despite higher absolute burden in men. These findings support gender-tailored case-finding, risk-factor management, and perioperative counseling, while highlighting the need for more consistent sex-stratified reporting in vascular research.

Keywords: Peripheral Artery Disease; Gender Differences; Ankle Brachial Index; Cardiovascular Risk Factors; Revascularization Outcomes; Medical Treatment Disparities; Mortality and Morbidity; Health-Related Quality of Life; Sexual Dimorphism; Clinical Presentation

Review Stats

Final search date and database lock: 2026-03-28 10:57:07 CET
Plan: Pro (expanded craft tokens; source: Semantic Scholar)
Source: Semantic Scholar
Total Abstracts/Papers: 1825
Downloaded Abstracts/Papers: 1000
Included original and non-original Abstracts/Papers (all): 228
Included original Abstracts/Papers (Vote counting by direction of effect): 209
Reference Index (links used in paper): 67
Total participants (topic deduplicated ΣN): 3925814

Get access to the full paper

Unlock the full evidence map

Full paper access includes the complete human-readable review, figures, reference index, PDF export, and machine-readable Evidence JSON download.
Evidence JSON can also be purchased separately if you only need the LLM-ready object for agent, AI, or RAG workflows.
Institutional or library access? Sign in with your institution email to open all available SAIMSARA papers under your institution access arrangement.
Need a SAIMSARA review on your own topic? ☸️Request.

Reference Index (67)

[1] The Pink Tax: Sex and Gender Disparities in Peripheral Artery Disease — https://doi.org/10.15420/usc.2022.28
[2] Gender Differences and Amputation Risk in Peripheral Artery Disease—A Single-Center Experience — https://doi.org/10.3390/diagnostics13193145
[3] Abstract WP180: Gender-specific Risk Of Stroke In Patients With Peripheral Artery Disease — https://doi.org/10.1161/str.54.suppl_1.wp180
[4] Foot Temperature by Infrared Thermography in Patients with Peripheral Artery Disease before and after Structured Home-Based Exercise: A Gender-Based Observational Study — https://doi.org/10.3390/jpm13091312
[5] Gender Differences in Outpatient Peripheral Artery Disease Management in Germany: A Population Based Study 2009-2018. — https://doi.org/10.1016/j.ejvs.2022.02.007
[6] A Systematic Review and Meta-analysis of Gender Differences in Long-term Mortality and Cardiovascular Events in Peripheral Artery Disease. — https://doi.org/10.1016/j.jvs.2020.09.039
[7] Gender Differences in the Medical Treatment of Peripheral Artery Disease — https://doi.org/10.3390/jcm10132855
[8] Burden of Peripheral Artery Disease and Its Attributable Risk Factors in 204 Countries and Territories From 1990 to 2019 — https://doi.org/10.3389/fcvm.2022.868370

Unlock the full paper to view the complete Reference Index.