This paper shows that statins remain one of the strongest cardiovascular therapies, consistently linked to fewer major events and lower mortality across very large populations, but not without trade-offs such as diabetes risk, muscle symptoms, and rises in lipoprotein(a). The full paper is worth reading because it shows where the benefit is most convincing, where the risks matter most, and how to think more clearly about the real balance between protection and harm.
Abstract: This paper aims to comprehensively synthesize the current evidence on the multifaceted effects of statin therapy, encompassing both its benefits and risks across various physiological systems and patient populations, to identify key clinical implications and future research directions. The review utilises 4734 original studies with 141,699,669 total participants (topic deduplicated ΣN). Across this evidence map, statin therapy most consistently aligns with improved cardiovascular outcomes in high-risk settings, including signals supporting reduced major adverse cardiovascular events and mortality, while also highlighting recurrent safety trade-offs such as higher risk of incident type 2 diabetes and increases in lipoprotein(a). Beyond lipid lowering, the mapped literature repeatedly points to pleiotropic pathways—anti-inflammatory and plaque-stabilizing effects—appearing across domains such as heart failure, stroke, and infectious/critical illness outcomes. At the same time, associations with musculoskeletal symptoms and other system-specific adverse outcomes underscore the need for individualized risk–benefit discussions and monitoring, particularly in susceptible subgroups. Interpretation is limited by the scoping design and the LLM-assisted classification workflow, which prioritize breadth over causal certainty and may introduce misclassification. Clinically, the map supports early and sustained statin use where cardiovascular risk is high while motivating research to better stratify diabetes risk and to clarify the clinical significance of statin-associated lipoprotein(a) increases.
Final search date and database lock: 2026-03-10 14:32:56 CET
Plan: Pro (expanded craft tokens; source: PubMed)
Source: PubMed
Total Abstracts/Papers: 32271
Downloaded Abstracts/Papers: 8950
Included original and non-original Abstracts/Papers (all): 5577
Included original Abstracts/Papers (Vote counting by direction of effect): 4734
Reference Index (links used in paper): 369
Total participants (topic deduplicated ΣN): 141699669
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The Evidence Object JSON is a separate machine-readable evidence product: a concentrated synthesis of results, topic-level evidence, and discussion across original and non-original studies. It can be directly input into your LLM, agent, or RAG workflow.
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[62] Preoperative Statin Exposure Reduces Periprosthetic Fractures and Revisions following Total Knee Arthroplasty. — https://doi.org/10.1055/s-0042-1755359
[76] Statin Therapy Is Associated With a Lower Risk of Heart Failure in Patients With Atrial Fibrillation: A Population-Based Study. — https://doi.org/10.1161/jaha.123.032378
[86] Does Preoperative Statin Exposure Reduce Prosthetic Joint Infections and Revisions Following Total Joint Arthroplasty? — https://doi.org/10.52198/23.sti.43.os1717
[89] Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. — https://doi.org/10.1038/s41397-019-0125-x
[97] The effects of fenofibric acid alone and with statins on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. — https://doi.org/10.2337/dc10-0357
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[149] A comprehensive assessment of statin discontinuation among patients who concurrently initiate statins and CYP3A4-inhibitor drugs; a multistate transition model. — https://doi.org/10.1111/bcp.15373
[169] The Effectiveness and Safety of Intensive Lipid-Lowering with Different Rosuvastatin-Based Regimens in Patients at High Cardiovascular Disease Risk: A Nonblind, Randomized, Controlled Trial. — https://doi.org/10.31083/j.rcm2408222
[183] Statin reduces the risk of dementia in diabetic patients receiving androgen deprivation therapy for prostate cancer. — https://doi.org/10.1038/s41391-018-0091-4
[203] The outcomes of statin therapy in patients with acute ischemic stroke in Taiwan: a nationwide epidemiologic study. — https://doi.org/10.1093/qjmed/hcz189
[207] Common Statin Intolerance Variants in and Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records. — https://doi.org/10.3389/fgene.2021.713181
[216] Guideline-directed statin intensification in patients with new or worsening symptoms of peripheral artery disease. — https://doi.org/10.1002/clc.23087
[232] Effect of Statins in Patients With Hemodialysis-Dependent Chronic Kidney Disease: A Nationwide Cohort Study. — https://doi.org/10.1161/jaha.125.043214
[236] Efficacy and safety of ezetimibe coadministered with statins: randomised, placebo-controlled, blinded experience in 2382 patients with primary hypercholesterolemia. — https://doi.org/10.1111/j.1368-5031.2004.00289.x
[242] Adjunctive statin therapy reduces intracranial hemorrhage and 1-year mortality in patients with atrial fibrillation after acute ischemic stroke: A population-based epidemiological study from Taiwan. — https://doi.org/10.1016/j.jocn.2019.07.045
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[300] The Impact of Statin Treatment Duration on the Risk of New-Onset Diabetes Mellitus and Recurrent Vascular Events in Ischemic Stroke Patients: A Linked Data Analysis. — https://doi.org/10.1159/000538485
[309] Pharmacogenomic insights into treatment and management of statin-induced myopathy. — https://doi.org/10.1186/gm120
[311] Reduced risk of hepatocellular carcinoma in the use of fibrate as an add-on to statin: A retrospective population-based cohort study. — https://doi.org/10.1016/j.ejca.2025.116094
[316] Long-term effects of ezetimibe-plus-statin therapy on low-density lipoprotein cholesterol levels as compared with double-dose statin therapy in patients with coronary artery disease. — https://doi.org/10.1016/j.atherosclerosis.2012.07.036
[376] Association of lipid-lowering agent use and dry eye disease: A nationwide matched case-control study in Taiwan, 2002-2016. — https://doi.org/10.1111/aos.15656
[384] [ANMCO Position paper: Diagnostic and therapeutic pathways in patients with hypercholesterolemia and statin intolerance]. — https://doi.org/10.1714/2262.24348
[480] Paradoxical effect of statin medication on depressive disorder in first-ever ischemic stroke patients: possible antidepressant-like effect prestroke and the opposite in continuous medication poststroke. — https://doi.org/10.1097/yic.0000000000000352
[503] Prior statin therapy and mortality among critically ill patients: a systemic review and meta-analysis of cohort studies. — https://doi.org/10.21037/atm.2020.02.101
[524] Statin Therapy for Hyperlipidemic Patients With Chronic Kidney Disease and End-Stage Renal Disease: A Retrospective Cohort Study Based on 925,418 Adults in Taiwan. — https://doi.org/10.3389/fphar.2022.815882
[530] Statin intensity and postoperative mortality following open repair of intact abdominal aortic aneurysm. — https://doi.org/10.1002/bjs5.94
[540] Rebound phenomenon of inflammatory response may be a major mechanism responsible for increased cardiovascular events after abrupt cessation of statin therapy. — https://doi.org/10.1016/j.mehy.2005.06.035
[543] Coronary artery calcium scoring in patients with statin associated muscle symptoms: Prescribing statins for those most likely to benefit. — https://doi.org/10.1016/j.jacl.2021.09.052
[548] Cross-sectional and longitudinal associations between statin use and bone density: the Manitoba BMD registry. — https://doi.org/10.1093/jbmr/zjaf077
[577] Consistency in efficacy and safety of ezetimibe coadministered with statins for treatment of hypercholesterolemia in women and men. — https://doi.org/10.1089/jwh.2004.13.1101
[589] Effect of Statin Therapy on Fibrous Cap Thickness in Coronary Plaque on Optical Coherence Tomography - Review and Meta-Analysis. — https://doi.org/10.1253/circj.cj-18-1376
[605] Lipid-altering efficacy and safety profile of combination therapy with ezetimibe/statin vs. statin monotherapy in patients with and without diabetes: an analysis of pooled data from 27 clinical trials. — https://doi.org/10.1111/j.1463-1326.2011.01383.x
[616] ANMCO Position Paper: diagnostic-therapeutic pathway in patients with hypercholesterolaemia and statin intolerance. — https://doi.org/10.1093/eurheartj/sux020
[619] Methodological issues of retrospective studies assessing health outcomes of potential clopidogrel-statin interaction. — https://doi.org/10.1111/ijpp.12085
[621] The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms. — https://doi.org/10.1002/cpt.2557
[624] Long-Term Statin Use Is Associated With Reduced Rates of Adverse Events in Patients With Newly Diagnosed Atrial Fibrillation. — https://doi.org/10.1161/jaha.124.035827
[632] Veterans Health Administration: Implementation of pharmacogenomic clinical decision support with statin medications and the SLCO1B1 gene as an exemplar. — https://doi.org/10.1093/ajhp/zxad111
[635] Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea. — https://doi.org/10.3390/jpm12040559
[657] Collective impact of conventional cardiovascular risk factors and coronary calcium score on clinical outcomes with or without statin therapy: The St Francis Heart Study. — https://doi.org/10.1016/j.atherosclerosis.2016.09.060
[659] A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial. — https://doi.org/10.4065/80.5.587
[665] Analysis of vitamin D levels in patients with and without statin-associated myalgia - a systematic review and meta-analysis of 7 studies with 2420 patients. — https://doi.org/10.1016/j.ijcard.2014.10.118
[721] Association of Cognitive Impairment in Patients on 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitors. — https://doi.org/10.14740/jocmr3066w
[727] Time-varying and dose-dependent effect of long-term statin use on risk of type 2 diabetes: a retrospective cohort study. — https://doi.org/10.1186/s12933-020-01037-0
[734] Effect of Statin Intensity on Cardiovascular Outcomes and Survival Following Coronary Artery Bypass Grafting. — https://doi.org/10.1002/clc.70170
[736] Statin uses in adults with non-dialysis advanced chronic kidney disease: Focus on clinical outcomes of infectious and cardiovascular diseases. — https://doi.org/10.3389/fphar.2022.996237
[789] Statin therapy is associated with improved perioperative outcomes and long-term mortality following carotid revascularization in the Vascular Quality Initiative. — https://doi.org/10.1016/j.jvs.2022.08.019
[795] The effect of preoperative statin treatment on acute kidney injury in elderly patients undergoing valve replacement surgery. — https://doi.org/10.1007/s00228-021-03252-4
[801] Use of fenofibrate on cardiovascular outcomes in statin users with metabolic syndrome: propensity matched cohort study. — https://doi.org/10.1136/bmj.l5125
[860] Risk of new-onset diabetes among patients treated with statins according to hypertension and gender: Results from a nationwide health-screening cohort. — https://doi.org/10.1371/journal.pone.0195459
[876] High-intensity Statin Treatments in Clinically Stable Patients on Aspirin Monotherapy 12 Months After Drug-eluting Stent Implantation: A Randomized Study. — https://doi.org/10.1016/j.rec.2017.06.008
[899] Statin use for primary prevention of cardiovascular disease reduces the risk of incident IBD: A population-based cohort study. — https://doi.org/10.1111/joim.70034
[901] Safety and efficacy of moderate-intensity statin with ezetimibe in elderly patients with atherosclerotic cardiovascular disease. — https://doi.org/10.1111/joim.20029
[920] Efficacy and Safety of Fenofibrate-Statin Combination Therapy in Patients With Inadequately Controlled Triglyceride Levels Despite Previous Statin Monotherapy: A Multicenter, Randomized, Double-blind, Phase IV Study. — https://doi.org/10.1016/j.clinthera.2021.08.005
[932] Association Between Statin Use and Inflammatory Bowel Diseases: Results from a Swedish, Nationwide, Population-based Case-control Study. — https://doi.org/10.1093/ecco-jcc/jjaa235
[946] Association between long-term statin use and cataract surgery: a nationwide study on 505 105 cataract surgery patients. — https://doi.org/10.1136/bjo-2022-322409
[955] Impact of statin on long-term outcome among patients with end-stage renal disease with acute myocardial infarction (AMI): a nationwide case-control study. — https://doi.org/10.1136/postgradmedj-2019-137292
[961] Statin use was associated with reduced mortality in both ischemic and nonischemic cardiomyopathy and in patients with implantable defibrillators: mortality data and mechanistic insights from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). — https://doi.org/10.1016/j.ahj.2007.02.002
[967] Coronary Artery Calcium Versus Pooled Cohort Equations Score for Primary Prevention Guidance: Randomized Feasibility Trial. — https://doi.org/10.1016/j.jcmg.2021.11.006
[985] Low-density lipoprotein cholesterol reduction and target achievement after switching from statin monotherapy to statin/ezetimibe combination therapy: Real-world evidence. — https://doi.org/10.1111/jcpt.13271
[988] Effectiveness and tolerability of ezetimibe co-administered with statins versus statin dose-doubling in high-risk patients with persistent hyperlipidemia: The EZE(STAT)2 trial. — https://doi.org/10.5114/aoms.2011.25550
[991] The Effect of Statins in Cancer Risk Reduction in Patients on Dialysis: A Population-Based Case-Control Study. — https://doi.org/10.3390/jcm10235602
[1062] Coronary Artery Calcification, Statin Use and Long-Term Risk of Atherosclerotic Cardiovascular Disease Events (from the Multi-Ethnic Study of Atherosclerosis). — https://doi.org/10.1016/j.amjcard.2019.12.031
[1073] Association between statin therapy and mortality in patients on dialysis after atherosclerotic cardiovascular diseases. — https://doi.org/10.1038/s41598-023-37819-1
[1087] Low utilization of statins in patients with dermatomyositis/polymyositis and hyperlipidemia: a multicenter USA-based study (2013-2023). — https://doi.org/10.1007/s10067-023-06801-7
[1091] Increased risk of developing peripheral artery disease in hemodialysis patients receiving statin treatments: a population-based cohort study in Taiwan. — https://doi.org/10.1093/ndt/gfz251
[1193] Prognostic value of coronary artery calcium score, area, and density among individuals on statin therapy vs. non-users: The coronary artery calcium consortium. — https://doi.org/10.1016/j.atherosclerosis.2020.10.009
[1269] Statin use increased new-onset diabetes in hypercholesterolemic individuals: Data from the Korean National Health Insurance Service-National Health Screening Cohort database (NHIS-HEALS). — https://doi.org/10.1016/j.pcd.2019.08.005
[1270] Efficacy of Statin therapy in post-stroke seizure prophylaxis: Clues from an observational study of routine secondary prevention treatment. — https://doi.org/10.1016/j.seizure.2019.07.010
[1292] Statins and long-term risk of revision surgery after total hip arthroplasty in osteoarthritis: a multi-source data linkage study. — https://doi.org/10.3389/fphar.2025.1492200
[1302] Preoperative Statin Treatment Is Not Associated with Reduced Postoperative Mortality or Morbidity in Patients Undergoing Isolated Valve Surgery. — https://doi.org/10.1532/hsf.2119
[1303] Perioperative Statin Use and Acute Kidney Injury in Patients Undergoing Partial Nephrectomy. — https://doi.org/10.3233/kca-180031
[1323] Coronary artery calcium score plays an important role for cardiovascular risk stratification in the statin benefit groups of asymptomatic individuals. — https://doi.org/10.1186/s12944-017-0560-0
[1353] Impact of statins on risk of new onset diabetes mellitus: a population-based cohort study using the Korean National Health Insurance claims database. — https://doi.org/10.2147/tcrm.s117150
[1384] Association of Continuation of Statin Therapy Initiated Before Transition to Chronic Dialysis Therapy With Mortality After Dialysis Initiation. — https://doi.org/10.1001/jamanetworkopen.2018.2311
[1397] High-intensity versus moderate-intensity statin treatment for patients with ischemic stroke: Nationwide cohort study. — https://doi.org/10.1177/23969873231193288
[1415] Impact of Statins on Survival and Limb Salvage in Patients Undergoing Peripheral Endovascular Intervention for Chronic Limb-Threatening Ischemia. — https://doi.org/10.1016/j.avsg.2022.11.010
[1437] Relation of Absence of Coronary Artery Calcium to Cardiovascular Disease Mortality Risk Among Individuals Meeting Criteria for Statin Therapy According to the 2018/2019 ACC/AHA Guidelines. — https://doi.org/10.1016/j.amjcard.2020.08.050
[1440] Preadmission Statin Therapy Is Associated with a Lower Incidence of Acute Kidney Injury in Critically Ill Patients: A Retrospective Observational Study. — https://doi.org/10.3390/jcm8010025
[1458] Time- and Dose-Dependent Association of Statin Use With Risk of Clinically Relevant New-Onset Diabetes Mellitus in Primary Prevention: A Nationwide Observational Cohort Study. — https://doi.org/10.1161/jaha.118.011320
[1465] Statin Treatment and Clinical Outcomes of Heart Failure Among Africans: An Inverse Probability Treatment Weighted Analysis. — https://doi.org/10.1161/jaha.116.004706
[1472] Statin use improves survival of patients with known or suspected lower extremity artery disease on all ankle brachial index levels. — https://doi.org/10.1024/0301-1526/a001041
[1502] Addition of Bempedoic Acid to Statin-Ezetimibe versus Statin Titration in Patients with High Cardiovascular Risk: A Single-Centre Prospective Study. — https://doi.org/10.3390/jcdd11090286
[1529] Association between statin use and dry eye disease in patients with hyperlipidemia: A population-based retrospective cohort study. — https://doi.org/10.1111/cts.70039
[1660] A Retrospective Cohort Study Assessing the Impact of Statin Therapy on Hospital Length of Stay and Inpatient Mortality in COVID-19 Patients. — https://doi.org/10.36518/2689-0216.1546
[1692] The influence of statin-fibrate combination therapy on lipids profile and apolipoprotein A5 in patients with acute coronary syndrome. — https://doi.org/10.1186/1476-511x-12-133
[1710] The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China. — https://doi.org/10.2147/clep.s360395
[1777] Impact of statin use on short- and long-term outcomes in patients with sepsis-induced myocardial injury: insights from the MIMIC-IV database. — https://doi.org/10.3389/fphar.2025.1520107
[1780] Addition of fenofibrate to statins is associated with risk reduction of diabetic retinopathy progression in patients with type 2 diabetes and metabolic syndrome: A propensity-matched cohort study. — https://doi.org/10.1016/j.diabet.2023.101428
[1790] The Diabetogenic Effect of Statin Use May Interact With Polygenic Risk Scores for Type 2 Diabetes: Evidence From the UK Biobank. — https://doi.org/10.3961/jpmph.24.671
[1794] SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort. — https://doi.org/10.1038/s41397-023-00307-w
[1846] Statin Trials, Cardiovascular Events, and Coronary Artery Calcification: Implications for a Trial-Based Approach to Statin Therapy in MESA. — https://doi.org/10.1016/j.jcmg.2017.01.029
[1853] Myasthenia gravis following the initiation of statin therapy: A multinational self-controlled case series study. — https://doi.org/10.1111/joim.70072
[1857] Comparative Efficacy and Safety of Statin Monotherapy and Statin plus Ezetimibe Combination in a Real-World Setting. — https://doi.org/10.3390/diseases11040168
[1871] Effects of statin therapy on cerebrovascular and renal outcomes in patients with predialysis advanced chronic kidney disease and dyslipidemia. — https://doi.org/10.1016/j.jacl.2017.01.001
[1891] Risk of New-Onset Diabetes Mellitus Among Adults Using Statins: A Retrospective Cohort Study in Thailand. — https://doi.org/10.7759/cureus.77749
[1907] Clinical usefulness of additional treatment with ezetimibe in patients with coronary artery disease on statin therapy. - From the viewpoint of cholesterol metabolism.-. — https://doi.org/10.1253/circj.cj-11-0391
[2043] Association between statin use and cataract formation in a retrospective cohort study using Japanese health screening and claims data. — https://doi.org/10.1038/s41598-025-97889-1
[2056] Comparison of arterial remodeling and changes in plaque composition between patients with progression versus regression of coronary atherosclerosis during statin therapy (from the TRUTH study). — https://doi.org/10.1016/j.amjcard.2011.12.016
[2159] Association between Statin use and Incident Peripheral Artery Disease According to Race, Age, and Presence of Depression in the Multi-Ethnic Study of Atherosclerosis. — https://doi.org/10.1016/j.avsg.2023.11.030
[2162] Benefits of Statin Therapy in Patients With Acute Myocardial Infarction With Serum Low-Density Lipoprotein Cholesterol ≤ 50 mg/dl. — https://doi.org/10.1016/j.amjcard.2017.04.003
[2187] Comparative effectiveness of moderate-intensity statin with ezetimibe therapy versus high-intensity statin monotherapy in patients with acute coronary syndrome: a nationwide cohort study. — https://doi.org/10.1038/s41598-024-51310-5
[2191] Risk of Incident Osteoarthritis of the Hand in Statin Initiators: A Sequential Cohort Study. — https://doi.org/10.1002/acr.23616
[2216] Associations of statin use with 30-day adverse outcomes among 4 801 406 US Veterans with and without SARS-CoV-2: an observational cohort study. — https://doi.org/10.1136/bmjopen-2021-058363
[2257] Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial. — https://doi.org/10.1016/s0140-6736(22)00916-3
[2268] Usefulness of baseline statin therapy in non-obstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) study. — https://doi.org/10.1371/journal.pone.0207194
[2351] Statin Use and Mortality among Patients Hospitalized with Sepsis: A Retrospective Cohort Study within Southern California, 2008-2018. — https://doi.org/10.1155/2022/7127531
[2378] Effect of atorvastatin on the incidence of acute kidney injury following valvular heart surgery: a randomized, placebo-controlled trial. — https://doi.org/10.1007/s00134-016-4358-8
[2389] Role of Gut Microbiota in Statin-Associated New-Onset Diabetes-A Cross-Sectional and Prospective Analysis of the FINRISK 2002 Cohort. — https://doi.org/10.1161/atvbaha.123.319458
[2415] Association of antecedent statin use on 30-day, 60-day and 90-day mortality among Mississippi Medicaid beneficiaries diagnosed with COVID-19. — https://doi.org/10.1136/bmjopen-2023-076195
[2445] A genetic risk score is significantly associated with statin therapy response in the elderly population. — https://doi.org/10.1111/cge.12890
[2452] Association between antecedent statin use and severe disease outcomes in COVID-19: A retrospective study with propensity score matching. — https://doi.org/10.1016/j.jacl.2021.03.002
[2455] Trends in statin utilization among adults with severe peripheral artery disease including critical limb ischemia in an integrated healthcare delivery system. — https://doi.org/10.1177/1358863x19871100
[2479] Lipid-altering efficacy of ezetimibe/simvastatin 10/40 mg compared with doubling the statin dose in patients admitted to the hospital for a recent coronary event: the INFORCE study. — https://doi.org/10.1111/j.1742-1241.2008.01697.x
[2584] Association between statin use and consultation or surgery for osteoarthritis of the hip or knee: a pooled analysis of four cohort studies. — https://doi.org/10.1016/j.joca.2017.07.013
[2662] Impact of Statin Therapy on Long-Term Survival of Patients with Chronic Kidney Disease but Without Atherosclerotic Cardiovascular Disease: Insights from the American MIMIC-IV and Chinese CIN-II Databases. — https://doi.org/10.1007/s11596-025-00139-8
[2680] Association of statins with diabetes mellitus and diabetic complications: role of confounders during follow-up. — https://doi.org/10.1136/jim-2016-000218
[2681] Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort. — https://doi.org/10.1007/s00125-015-3528-5
[2694] Statin use during intensive care unit stay is associated with improved clinical outcomes in critically ill patients with sepsis: a cohort study. — https://doi.org/10.3389/fimmu.2025.1537172
[2696] The impact of statin use prior to intensive care unit admission on critically ill patients with sepsis. — https://doi.org/10.1002/phar.2506
[2707] Associations Between Statin Use and Negative Affective Bias During COVID-19: An Observational, Longitudinal UK Study Investigating Depression Vulnerability. — https://doi.org/10.1016/j.biopsych.2022.03.009
[2723] Comparison of Renal Effects of Ezetimibe-Statin Combination versus Statin Monotherapy: A Propensity-Score-Matched Analysis. — https://doi.org/10.3390/jcm9030798
[2756] Efficacy and safety of fenofibric acid co-administered with low- or moderate-dose statin in patients with mixed dyslipidemia and type 2 diabetes mellitus: results of a pooled subgroup analysis from three randomized, controlled, double-blind trials. — https://doi.org/10.2165/10061630-000000000-00000
[2814] Statin Use is Associated With Lower Odds of IBD-Related Surgery Among Patients With Moderate-to-Severe Inflammatory Bowel Disease. — https://doi.org/10.1093/ibd/izaf227
[2891] Moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with metabolic syndrome and atherosclerotic cardiovascular disease: A post-hoc analysis of the RACING trial. — https://doi.org/10.1111/dom.15374
[2906] Effect of Statin Therapy on Cardiovascular Outcome in Stroke Patients with Low Baseline Low-Density Lipoprotein Cholesterol. — https://doi.org/10.1002/ana.26895
[2907] Effect of preoperative moderate-dose statin and duration on acute kidney injury after cardiac surgery: a retrospective cohort study. — https://doi.org/10.1080/03007995.2023.2286317
[2934] Association of statin use and the risk of end-stage renal disease: A nationwide Asian population-based case-control study. — https://doi.org/10.1016/j.ejim.2016.02.012
[3014] Effect of Statin Intensity on the Risk of Epilepsy After Ischaemic Stroke: Real-World Evidence from Population-Based Health Claims. — https://doi.org/10.1007/s40263-018-0501-0
[3030] Uncertainty in the estimated effects of statin initiation on risk of dementia: using a multiverse analysis to assess sources of variability. — https://doi.org/10.1007/s10654-025-01231-y
[3033] Statin use in patients with type 2 diabetes has lower risk of hip fractures: A Taiwan national population-based study. — https://doi.org/10.1002/dmrr.3603
[3035] Statins and Cognitive Decline in the Cardiovascular Health Study: A Comparison of Different Analytical Approaches. — https://doi.org/10.1093/gerona/glab220
[3044] Statin prescribing for prevention of cardiovascular disease amongst people with severe mental illness: Cohort study in UK primary care. — https://doi.org/10.1016/j.schres.2017.05.028
[3047] Statin treatment is associated with a decreased risk of active tuberculosis: an analysis of a nationally representative cohort. — https://doi.org/10.1136/thoraxjnl-2015-207052
[3096] CAC Score Improves Coronary and CV Risk Assessment Above Statin Indication by ESC and AHA/ACC Primary Prevention Guidelines. — https://doi.org/10.1016/j.jcmg.2016.03.022
[3108] Intensive Statin Therapy Versus Upfront Combination Therapy of Statin and Ezetimibe in Patients With Acute Coronary Syndrome: A Propensity Score Matching Analysis Based on the PL-ACS Data. — https://doi.org/10.1161/jaha.123.030414
[3116] Preoperative statin administration does not protect against early postoperative acute respiratory distress syndrome: a retrospective cohort study. — https://doi.org/10.1213/ane.0000000000000387
[3133] Effect of moderate-intensity statin with ezetimibe combination vs. high-intensity statin therapy according to sex in patients with atherosclerosis. — https://doi.org/10.1038/s41598-023-47505-x
[3163] Association of Statin Use with Dementia Risk Among Older Adults in Japan: A Nested Case-Control Study Using the LIFE Study. — https://doi.org/10.3233/jad-240113
[3170] Statin Use Correlates with Reduced Risk of Pyogenic Liver Abscess: A Population-Based Case-Control Study. — https://doi.org/10.1111/bcpt.12777
[3232] Prognostic Significance of Statins in Ischemic and Non-ischemic Heart Failure Patients with Reduced Ejection Fraction in Real Life. — https://doi.org/10.5543/tkda.2022.22424
[3295] Association between statin therapy as primary prevention and mortality in adults 50 years and older with chronic kidney disease without other indications. — https://doi.org/10.1080/02813432.2026.2636586
[3300] Association between statin compliance and risk of dementia among patients with chronic periodontitis. — https://doi.org/10.1111/odi.14784
[3435] Statin use associated with a reduced risk of pneumonia requiring hospitalization in patients with myocardial infarction: a nested case-control study. — https://doi.org/10.1186/s12872-016-0202-x
[3473] Lipoprotein levels and statin treatment related to dementia and cognitive decline in individuals with type 2 diabetes: an observational analysis from the ADVANCE study. — https://doi.org/10.1186/s12933-025-02894-3
[3486] Impact of initial very low-level low-density lipoprotein cholesterol on the prognosis of acute myocardial infarction patients. — https://doi.org/10.1097/mca.0000000000001085
[3508] Assessment of Coronary Artery Calcium Scoring for Statin Treatment Strategy according to ACC/AHA Guidelines in Asymptomatic Korean Adults. — https://doi.org/10.3349/ymj.2017.58.1.82
[3529] Projected cost-effectiveness of ezetimibe/simvastatin compared with doubling the statin dose in the United Kingdom: findings from the INFORCE study. — https://doi.org/10.1111/j.1524-4733.2010.00742.x
[3582] Reduction in life-threatening ventricular tachyarrhythmias in statin-treated patients with nonischemic cardiomyopathy enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy). — https://doi.org/10.1016/j.jacc.2012.03.041
[3596] Nationwide Big Data Analysis of Statin Use and Intracerebral Hemorrhage Risk in Acute Ischemic Stroke Patients in Taiwan. — https://doi.org/10.3390/medicina60060939
[3609] Effect of Probucol and/or Cilostazol on Carotid Intima Media Thickness in Patients with Coronary Heart Disease: A Randomized, Multicenter, Multinational Study. — https://doi.org/10.5551/jat.55616
[3782] Use of Continuous Exposure Variables when Examining Dose-Dependent Pharmacological Effects - Application to the Association between Exposure to Higher Statin Doses and the Incidence of Diabetes. — https://doi.org/10.22374/1710-6222.24.1.1
[3856] Statin use is associated with lower risk of dementia in stroke patients: a community-based cohort study with inverse probability weighted marginal structural model analysis. — https://doi.org/10.1007/s10654-022-00856-7
[3878] Statin therapy prior to hospitalization does not significantly influence sepsis presentation or sepsis outcomes. A prospective, observational study. — https://doi.org/10.1016/j.medcli.2020.02.010
[3908] Do outpatient statins and ACEIs/ARBs have synergistic effects in reducing the risk of pneumonia? A population-based case-control study. — https://doi.org/10.1371/journal.pone.0199981
[3958] Lipid-lowering effect of preoperative statin therapy on postoperative major adverse cardiac events after coronary artery bypass surgery. — https://doi.org/10.1016/j.jtcvs.2007.07.029
[4011] Effect of intensive statin therapy on clinical outcomes among patients undergoing percutaneous coronary intervention for acute coronary syndrome. PCI-PROVE IT: A PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) Substudy. — https://doi.org/10.1016/j.jacc.2009.09.010
[4034] Influence of statin-potency on the risk of kidney disease - A nationwide cohort study using laboratory data. — https://doi.org/10.1002/pds.5173
[4073] The Effect of Statins on Clinical Outcome Among Hospitalized Patients With COVID-19: A Multi-Centric Cohort Study. — https://doi.org/10.3389/fphar.2022.742273
[4078] Implications of the 2019 American College of Cardiology/American Heart Association Primary Prevention Guidelines and potential value of the coronary artery calcium score among South Asians in the US: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. — https://doi.org/10.1016/j.atherosclerosis.2021.08.030
[4082] Prescription of statins at discharge and 1-year risk of major clinical outcomes among acute coronary syndromes patients with extremely low LDL-cholesterol in clinical pathways for acute coronary syndromes studies. — https://doi.org/10.1002/clc.23040
[4107] Hydrophilic and lipophilic statin use and risk of hearing loss in hyperlipidemia using a Common Data Model: multicenter cohort study. — https://doi.org/10.1038/s41598-023-39316-x
[4129] Long-term safety and efficacy of fenofibric acid in combination with statin therapy for the treatment of patients with mixed dyslipidemia. — https://doi.org/10.1016/j.jacl.2008.10.001
[4146] Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink. — https://doi.org/10.1371/journal.pone.0193297
[4171] Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population-based cohort study. — https://doi.org/10.1111/bcp.13626
[4205] Impact of adding ezetimibe to statin to achieve low-density lipoprotein cholesterol goal (from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation [COURAGE] trial). — https://doi.org/10.1016/j.amjcard.2013.02.005
[4324] Platelet reactivity and clinical outcomes in patients using CYP3A4-metabolized statins with clopidogrel in percutaneous coronary intervention. — https://doi.org/10.1007/s00380-016-0927-6
[4444] Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study. — https://doi.org/10.1161/jaha.117.007524
[4450] Preexisting statin therapy is not associated with reduced acute kidney injury following cardiac surgery: a retrospective analysis. — https://doi.org/10.3389/fphar.2025.1613681
[4457] Association of early statin initiation during COVID-19 admission with inpatient mortality at an academic health system in Illinois, March 2020 to September 2022: a target trial emulation using observational data. — https://doi.org/10.1136/bmjopen-2024-085547
[4524] Fenofibrate therapy and risk of heart failure outcomes in patients with Type 2 diabetes: a propensity-matched cohort study. — https://doi.org/10.1093/ehjcvp/pvaf053
[4564] Effects of statin treatments on coronary plaques assessed by volumetric virtual histology intravascular ultrasound analysis. — https://doi.org/10.1016/j.jcin.2009.03.015
[4638] Efficacy and safety of moderate-intensity statin with ezetimibe combination therapy in patients after percutaneous coronary intervention: a post-hoc analysis of the RACING trial. — https://doi.org/10.1016/j.eclinm.2023.101933
[4664] Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study. — https://doi.org/10.1093/rheumatology/keaa044
[4668] Comparison of Low-Dose Statin Versus Low-Dose Statin + Armolipid Plus in High-Intensity Statin-Intolerant Patients With a Previous Coronary Event and Percutaneous Coronary Intervention (ADHERENCE Trial). — https://doi.org/10.1016/j.amjcard.2017.06.015
[4824] Statins and atherosclerotic cardiovascular outcomes in patients on incident dialysis and with atherosclerotic heart disease. — https://doi.org/10.1016/j.ahj.2020.10.055
[4839] Statin use and risk of Parkinson's disease among older adults in Japan: a nested case-control study using the Longevity Improvement and Fair Evidence study. — https://doi.org/10.1093/braincomms/fcae195
[4933] Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study. — https://doi.org/10.1016/j.diabet.2020.10.001
[4952] Effect of Switching From Statin Monotherapy to Ezetimibe/Simvastatin Combination Therapy Compared With Other Intensified Lipid-Lowering Strategies on Lipoprotein Subclasses in Diabetic Patients With Symptomatic Cardiovascular Disease. — https://doi.org/10.1161/jaha.114.001675
[4958] Statins and risks of dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong. — https://doi.org/10.1016/j.lanwpc.2023.101006
[4983] Effect of statin therapy on survival in patients with nonischemic dilated cardiomyopathy (from the Beta-blocker Evaluation of Survival Trial [BEST]). — https://doi.org/10.1016/j.amjcard.2006.12.080
[5038] Consistency of effect of ezetimibe/simvastatin compared with intensified lipid-lowering treatment strategies in obese and non-obese diabetic subjects. — https://doi.org/10.1186/1476-511x-12-103
[5126] Statin Use and Incidence of Parkinson's Disease in Women from the French E3N Cohort Study. — https://doi.org/10.1002/mds.29349
[5128] Statin treatment effectiveness and the SLCO1B1*5 reduced function genotype: Long-term outcomes in women and men. — https://doi.org/10.1111/bcp.15245
[5131] Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study. — https://doi.org/10.12997/jla.2021.10.3.322
[5180] Effect of Timing and Duration of Statin Exposure on Risk of Hip or Knee Revision Arthroplasty: A Population-based Cohort Study. — https://doi.org/10.3899/jrheum.180574
[5272] Association Between Preoperative Statin Exposure and Acute Kidney Injury in Adult Patients Undergoing Cardiac Surgery. — https://doi.org/10.1053/j.jvca.2021.07.031
[5312] One-year treatment trajectories of patients with statin intolerance: results from a multicentre registry. — https://doi.org/10.1093/eurjpc/zwaf619
[5342] Comparison of Effects of Statin Use on Mortality in Patients With Heart Failure and Preserved Versus Reduced Left Ventricular Ejection Fraction. — https://doi.org/10.1016/j.amjcard.2018.04.027
[5406] Statin Use is Associated with a Less Severe Disease Course In Inflammatory Bowel Disease: A Nationwide Cohort Study 2006-2020. — https://doi.org/10.1093/ibd/izaf077
[5409] Association between statin use and outcomes in patients with coronavirus disease 2019 (COVID-19): a nationwide cohort study. — https://doi.org/10.1136/bmjopen-2020-044421
[5420] Risk of new-onset diabetes mellitus during treatment with low-dose statins in Japan: A retrospective cohort study. — https://doi.org/10.1111/jcpt.12675
[5431] Adherence to statins is associated with reduced incidence of idiopathic venous thromboembolism: real-life data from a large healthcare maintenance organisation. — https://doi.org/10.1136/heartjnl-2012-302906
[5494] The impact of statin use before intensive care unit admission on patients with acute kidney injury after cardiac surgery. — https://doi.org/10.3389/fphar.2023.1259828
[5501] Sociodemographic modifiers of effects of statin initiation on dementia incidence: An emulated trial design in a large health care member population with 10+ years of follow-up. — https://doi.org/10.1002/alz.14627
[5520] Safety and tolerability of extended-release niacin-laropiprant: Pooled analyses for 11,310 patients in 12 controlled clinical trials. — https://doi.org/10.1016/j.jacl.2015.02.006
