Therapeutic Drug Monitoring (TDM) of Antibiotics: Scoping Review with ☸️SAIMSARA.

Name: SAIMSARA Evidence Object infections::TDM_ANTIBIOTICS_PM
Creator: SAIMSARA
License: https://saimsara.com/license/

SAIMSARA

doi:10.62487/saimsara002717c5

Therapeutic Drug Monitoring (TDM) of Antibiotics: Scoping Review with ☸️SAIMSARA.

Issue 7, Volume 1, 2026

Editorial note

• Last update: 2026-05-15 22:49:02

What is this paper about

Therapeutic drug monitoring of antibiotics turns dosing from guesswork into measurable precision, especially in critically ill, pediatric, burn, ECMO, renal-replacement, and other high-risk patients where standard regimens often miss PK/PD targets. This SAIMSARA evidence map is worth reading because it separates practical dosing signals from implementation noise, mapping β-lactams, vancomycin, aminoglycosides, toxicity thresholds, assay reliability, digital dosing tools, and stewardship workflows across 394 original studies.

Human-verified editorial review Verified by World ID proof-of-human. This editorial layer was submitted from a SAIMSARA account verified as a unique human.

Evidence preview · Did you know?

Modern ICU scene with antibiotic infusion, laboratory monitoring, and precision dosing dashboard.

Monitoring can change the dose

Did you know? In critically ill children, TDM-guided dose adjustment improved target attainment from 20% to 70%.

This makes antibiotic dosing measurable instead of relying only on standard regimens in unstable patients.

Clinical pharmacology visualization showing antibiotic concentration curves missing the therapeutic target zone.

Standard ICU dosing often misses

Did you know? β-lactam PK/PD targets were missed in 39.3% of critically ill adults in one ICU study.

Meropenem and piperacillin samples were also frequently non-target, showing why “usual dose” may be unreliable.

Hospital safety-control scene showing antibiotic toxicity alert, neurologic risk, and dosing safeguards.

Overexposure is also a safety issue

Did you know? Cefepime troughs above 20 mg/L were linked to a fivefold higher neurologic-event risk.

TDM is not only about reaching efficacy targets; it can also help prevent toxic antibiotic exposure.

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Abstract:

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Review Stats

Final search date and database lock: 2026-05-13 20:54:05 CEST

Plan: Pro (expanded craft tokens; source: PubMed)

Source: PubMed

Total Abstracts/Papers: 1053

Downloaded Abstracts/Papers: 1053

Included original and non-original Abstracts/Papers (all): 508

Included original Abstracts/Papers (Vote counting by direction of effect): 394

Reference Index (links used in paper): 175

Total participants/sample observations (topic deduplicated ΣN): 430680

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The full evidence review, including the Introduction, Methods, Results, Discussion, Conclusion, figures, and complete reference index, opens after purchase or sign-in. The Evidence Object JSON is a separate machine-readable evidence product: a concentrated synthesis of results, topic-level evidence, and discussion across original and non-original studies. It can be directly input into your LLM, agent, or RAG workflow.

Reference Index (175)

[1] Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper. — https://doi.org/10.1007/s00134-020-06050-1
[3] From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotics. — https://doi.org/10.1002/cpt.2202
[4] A guide to therapeutic drug monitoring of β-lactam antibiotics. — https://doi.org/10.1002/phar.2505
[7] The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustments. — https://doi.org/10.1016/s1473-3099(25)00155-0
[14] Therapeutic Drug Monitoring of Antibiotics in the Elderly: A Narrative Review. — https://doi.org/10.1097/ftd.0000000000000939
[17] Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients-A Narrative Review. — https://doi.org/10.3390/antibiotics12030568
[19] Unraveling the impact of therapeutic drug monitoring via machine learning for patients with sepsis. — https://doi.org/10.1016/j.xcrm.2024.101681
[20] Therapeutic drug monitoring in cystic fibrosis and associations with pulmonary exacerbations and lung function. — https://doi.org/10.1016/j.rmed.2023.107237
[22] Optical Biosensors for Therapeutic Drug Monitoring. — https://doi.org/10.3390/bios9040132
[24] Therapeutic Drug Monitoring of Amikacin and Colistin in Patients with Multidrug-Resistant Gram-Negative Infections Using a Portable Plasmonic Biosensor. — https://doi.org/10.1021/acs.analchem.4c06748
[26] Therapeutic drug monitoring status of four common antibiotics: vancomycin, meropenem, linezolid and teicoplanin. — https://doi.org/10.1080/00365513.2022.2137689
[27] Biosensors and nanobiosensors for therapeutic drug and response monitoring. — https://doi.org/10.1039/c5an01861g
[29] Therapeutic Drug Monitoring of Antibiotics in Critically Ill Patients: Current Practice and Future Perspectives With a Focus on Clinical Outcome. — https://doi.org/10.1097/ftd.0000000000000942
[30] [Therapeutic drug monitoring of beta-lactam antibiotics in critically ill adult patients]. — https://doi.org/10.1556/650.2023.32896
[31] Augmented renal clearance and therapeutic monitoring of β-lactams. — https://doi.org/10.1016/j.ijantimicag.2014.12.020
[32] Optimizing Therapeutic Drug Monitoring in Pregnant Women: A Critical Literature Review. — https://doi.org/10.1097/ftd.0000000000001039
[34] Emerging therapeutic drug monitoring of anti-infective agents in Australian hospitals: Availability, performance and barriers to implementation. — https://doi.org/10.1111/bcp.14995
[36] Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time. — https://doi.org/10.1016/j.ijantimicag.2023.107032
[42] Impact of therapeutic drug monitoring of antibiotics in the management of infective endocarditis. — https://doi.org/10.1007/s10096-022-04475-8
[43] Therapeutic drug monitoring of the β-lactam antibiotics: what is the evidence and which patients should we be using it for? — https://doi.org/10.1093/jac/dkv201
[45] Pharmacokinetics in children. — https://doi.org/10.1093/jac/34.suppl_a.19
[47] Saliva as a matrix for therapeutic drug monitoring and disease biomarkers in children and adolescents. — https://doi.org/10.1007/s43440-025-00732-7
[51] Clinical Response and Hospital Costs of Therapeutic Drug Monitoring for Vancomycin in Elderly Patients. — https://doi.org/10.3390/jpm12020163
[52] Therapeutic Drug Monitoring of Antibiotics in Critically Ill Children: An Observational Study in a Pediatric Intensive Care Unit. — https://doi.org/10.1097/ftd.0000000000000918
[53] Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients. — https://doi.org/10.3390/antibiotics12020373
[55] Amoxicillin therapeutic drug monitoring for endocarditis: A comparative study (EI-STAB). — https://doi.org/10.1016/j.ijantimicag.2023.106821
[56] DeepTDM: Deep Learning-Based Prediction of Sequential Therapeutic Drug Monitoring Levels of Vancomycin. — https://doi.org/10.1109/jtehm.2025.3623605
[57] Therapeutic Drug Monitoring-Guided Linezolid Therapy for the Treatment of Multiple Staphylococcal Brain Abscesses in a 3-Month-Old Infant. — https://doi.org/10.3390/pathogens14010004
[60] Assessment of the practical impact of adjusting beta-lactam dosages based on therapeutic drug monitoring in critically ill adult patients: a systematic review and meta-analysis of randomized clinical trials and observational studies. — https://doi.org/10.1038/s41598-024-58200-w
[65] Usefulness of therapeutic drug monitoring of piperacillin and meropenem in routine clinical practice: a prospective cohort study in critically ill patients. — https://doi.org/10.1136/ejhpharm-2018-001713
[71] Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study. — https://doi.org/10.1186/s13054-020-03397-1
[74] Appropriateness of gentamicin therapeutic drug monitoring at a Middle Eastern tertiary hospital setting: a retrospective evaluation and quality audit. — https://doi.org/10.1080/20523211.2024.2375753
[75] From Bed to Bench: Pre-analytical Stability of 29 Anti-infective Agents in Plasma and Whole Blood to Improve Accuracy of Therapeutic Drug Monitoring. — https://doi.org/10.1097/ftd.0000000000001237
[80] Therapeutic Drug Monitoring of Meropenem and Piperacillin in Critical Illness-Experience and Recommendations from One Year in Routine Clinical Practice. — https://doi.org/10.3390/antibiotics9030131
[84] Impact of Real-Time Therapeutic Drug Monitoring on the Prescription of Antibiotics in Burn Patients Requiring Admission to the Intensive Care Unit. — https://doi.org/10.1128/aac.01818-17
[88] [Therapeutic monitoring of antibiotics: New methodologies: biosensors]. — https://doi.org/10.4067/s0034-98872015000800013
[90] Non-invasive Drug Monitoring of β-Lactam Antibiotics Using Sweat Analysis-A Pilot Study. — https://doi.org/10.3389/fmed.2020.00476
[91] An LC-MS/MS method for the simultaneous determination of 18 antibacterial drugs in human plasma and its application in therapeutic drug monitoring. — https://doi.org/10.3389/fphar.2022.1044234
[96] [Development of hospital pharmacy practice using therapeutic drug monitoring]. — https://doi.org/10.1248/yakushi.14-00164
[99] Optimizing Treatment, Minimizing Risk: Therapeutic Drug Monitoring in Hematological Malignancies. — https://doi.org/10.4084/mjhid.2026.022
[100] Implementation of a β-lactam therapeutic drug monitoring program: Experience from a large academic medical center. — https://doi.org/10.1093/ajhp/zxac171
[101] How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients? — https://doi.org/10.1186/1471-2334-14-288
[102] UPLC-MS/MS Method for Simultaneous Determination of 14 Antimicrobials in Human Plasma and Cerebrospinal Fluid: Application to Therapeutic Drug Monitoring. — https://doi.org/10.1155/2022/7048605
[103] Pharmacologic optimization of antibiotics for Gram-negative infections. — https://doi.org/10.1097/qco.0000000000000601
[104] Therapeutic Drug Monitoring by Pharmacists: Does It Reduce Costs. — https://doi.org/10.36401/jqsh-19-40
[105] The importance of antibiotic treatment duration in antimicrobial resistance. — https://doi.org/10.1007/s10096-024-04867-y
[106] A comparison between venous blood sampling and capillary volumetric absorptive microsampling for antibiotics levels monitoring in individuals with and without periodontal disease. — https://doi.org/10.1007/s00784-025-06466-3
[107] The ONTAI study - a survey on antimicrobial dosing and the practice of therapeutic drug monitoring in German intensive care units. — https://doi.org/10.1016/j.jcrc.2020.08.027
[114] Therapeutic drug monitoring of beta-lactam antibiotics in burns patients--a one-year prospective study. — https://doi.org/10.1097/ftd.0b013e31824981a6
[120] Quantification of 15 Antibiotics Widely Used in the Critical Care Unit with a LC-MS/MS System: An Easy Method to Perform a Daily Therapeutic Drug Monitoring. — https://doi.org/10.3390/ph14121214
[125] Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial. — https://doi.org/10.1007/s00134-022-06921-9
[126] Dose individualisation of antibiotics in critically ill patients with inflammation: A narrative review. — https://doi.org/10.1002/bcp.70185
[127] LC-MS/MS analysis of five antibiotics in dried blood spots for therapeutic drug monitoring of ICU patients. — https://doi.org/10.1016/j.jchromb.2025.124699
[129] Evaluation of drugs and risk factors requiring therapeutic drug monitoring in the Neonatal Intensive Care Unit: a retrospective study. — https://doi.org/10.1186/s12887-026-06929-w
[130] Clinical applications of population pharmacokinetic models of antibiotics: Challenges and perspectives. — https://doi.org/10.1016/j.phrs.2018.07.005
[133] Impact of vancomycin therapeutic drug monitoring on patient care. — https://doi.org/10.1177/106002809402801201
[136] Personalized Antibiotic Therapy for the Critically Ill: Implementation Strategies and Effects on Clinical Outcome of Piperacillin Therapeutic Drug Monitoring-A Descriptive Retrospective Analysis. — https://doi.org/10.3390/antibiotics10121452
[137] Between-centre variation in antibiotic therapeutic drug monitoring and obtaining surveillance cultures in Dutch ICUs: A retrospective observational study. — https://doi.org/10.1016/j.jcrc.2026.155524
[139] Why is the Implementation of Beta-Lactam Therapeutic Drug Monitoring for the Critically Ill Falling Short? A Multicenter Mixed-Methods Study. — https://doi.org/10.1097/ftd.0000000000001059
[140] Pharmacist-led implementation of a vancomycin guideline across medical and surgical units: impact on clinical behavior and therapeutic drug monitoring outcomes. — https://doi.org/10.2147/iprp.s92850
[141] Physical and information workflow mapping of vancomycin therapeutic drug management: A single site case study revealing potential gaps in the process. — https://doi.org/10.1007/s10916-021-01784-x
[144] Impact of β-lactam antibiotic therapeutic drug monitoring on dose adjustments in critically ill patients undergoing continuous renal replacement therapy. — https://doi.org/10.1016/j.ijantimicag.2017.01.009
[146] International survey of antibiotic dosing and monitoring in adult intensive care units. — https://doi.org/10.1186/s13054-023-04527-1
[148] Hemorrhagic risk of concomitant direct oral anticoagulants and fluoroquinolones: integration of pharmacovigilance and therapeutic drug monitoring. — https://doi.org/10.3389/fphar.2026.1745035
[149] Flucloxacillin-warfarin interaction: an under-appreciated phenomenon. — https://doi.org/10.1111/imj.13944
[152] A retrospective cohort analysis of factors influencing continuous antibiotic therapy with ampicillin. — https://doi.org/10.1016/j.lfs.2024.123168
[153] Evaluation of continuous ampicillin/sulbactam infusion in critically ill patients. — https://doi.org/10.1016/j.lfs.2023.121567
[155] Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients. — https://doi.org/10.1016/j.burns.2015.01.001
[156] β-Lactam Dosage Regimens in Septic Patients with Augmented Renal Clearance. — https://doi.org/10.1128/aac.02534-17
[163] Antibiotics at the extremes of age: choices and constraints. — https://doi.org/10.1093/jac/34.suppl_a.11
[174] Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal. — https://doi.org/10.4414/smw.2016.14368
[178] Feasibility verification of fingerstick capillary microsampling replacing venipuncture for therapeutic drug monitoring of 12 antibiotics using a rapid LC-MS/MS assay. — https://doi.org/10.1016/j.talanta.2026.129894
[179] Pharmacokinetics of oral antimycobacterials and dosing guidance for Mycobacterium avium complex treatment in cystic fibrosis. — https://doi.org/10.1016/j.jcf.2021.04.011
[181] Recent Trends in Nanomaterial Based Electrochemical Sensors for Drug Detection: Considering Green Assessment. — https://doi.org/10.2174/0115680266286981240207053402
[182] Right dose, right now: using big data to optimize antibiotic dosing in the critically ill. — https://doi.org/10.5603/ait.a2015.0061
[186] Pharmacist-managed dose adjustment feedback using therapeutic drug monitoring of vancomycin was useful for patients with methicillin-resistant infections: a single institution experience. — https://doi.org/10.2147/idr.s109485
[191] Oral antibiotics lower mycophenolate mofetil drug exposure, possibly by interfering with the enterohepatic recirculation: A case series. — https://doi.org/10.1002/prp2.1103
[192] Recent Advances in Electrochemical Aptasensors for Detection of Clinical and Veterinary Drugs. — https://doi.org/10.1080/10408347.2025.2469781
[194] Determination of amoxicillin and cotrimoxazole concentrations in sputum of patients with cystic fibrosis. — https://doi.org/10.1002/bmc.5208
[199] Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review. — https://doi.org/10.1186/2110-5820-2-35
[202] The New Delhi metallo-β-lactamase-1 biosensor rapidly and accurately detected antibiotic plasma concentrations in cefuroxime-treated patients. — https://doi.org/10.1016/j.ijantimicag.2024.107229
[203] A case of recovery from aphasia following dose reduction of cefepime by bayesian prediction-based therapeutic drug monitoring. — https://doi.org/10.1016/j.jiac.2019.10.006
[204] Clinical and Procedural Evaluation of a Pharmacy Pharmacokinetic Consult Service. — https://doi.org/10.1177/0897190019826484
[209] Quantification of amikacin, gentamicin, and tobramycin in capillary plasma microsamples by LC-MS/MS. — https://doi.org/10.1016/j.jchromb.2025.124698
[211] Rapid Monitoring of Vancomycin Concentration in Serum Using Europium (III) Chelate Nanoparticle-Based Lateral Flow Immunoassay. — https://doi.org/10.3389/fchem.2021.763686
[213] Wearable microneedle-based electrochemical aptamer biosensing for precision dosing of drugs with narrow therapeutic windows. — https://doi.org/10.1126/sciadv.abq4539
[215] The dilemma of antibiotic susceptibility and clinical decision-making in a multi-drug-resistant bloodstream infection. — https://doi.org/10.3389/fphar.2023.1183332
[218] Appropriate Use of Vancomycin in NICU Despite Free-for-All Policy. — https://doi.org/10.5863/1551-6776-21.3.207
[219] Quantitative Determination of Unbound Piperacillin and Imipenem in Biological Material from Critically Ill Using Thin-Film Microextraction-Liquid Chromatography-Mass Spectrometry. — https://doi.org/10.3390/molecules27030926
[223] Navigating pharmacokinetic and pharmacodynamics challenges of β-lactam antibiotics in patients with low body weight: efficacy, toxicity, and dosage optimization. — https://doi.org/10.1177/20420986251320414
[225] Dosing of antimicrobial agents in critically-ill patients with acute kindey injury and continuous venvenous haemofiltration. — https://doi.org/10.1179/acb.2007.082
[226] Determination of Free Valproic Acid Concentration in 569 Clinical Samples by LC-MS/MS After Hollow Fiber Centrifugal Ultrafiltration Treatment. — https://doi.org/10.1097/ftd.0000000000000903
[227] Enhancing Stability and Investigating Target Attainment of Benzylpenicillin in Outpatient Parenteral Antimicrobial Therapy: Insights from In Vitro and In Vivo Evaluations. — https://doi.org/10.3390/antibiotics13100970
[238] Serum β-lactam concentrations in critically ill patients with cirrhosis: a matched case-control study. — https://doi.org/10.1111/liv.13039
[245] Advanced computer programs for drug dosing that combine pharmacokinetic and symbolic modeling of patients. — https://doi.org/10.1016/0010-4809(92)90033-7
[251] How can we ensure effective antibiotic dosing in critically ill patients receiving different types of renal replacement therapy? — https://doi.org/10.1016/j.diagmicrobio.2015.01.013
[254] Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases. — https://doi.org/10.1097/ftd.0b013e318260f7b3
[255] Simultaneous determination of eight β-lactam antibiotics in human plasma and cerebrospinal fluid by liquid chromatography coupled to tandem mass spectrometry. — https://doi.org/10.1016/j.jpba.2019.112904
[256] Simultaneous post-neurosurgical ventriculitis and bacteraemia by two different strains of KPC-producing K. pneumoniae successfully treated with meropenem/vaborbactam and high dose of fosfomycin. — https://doi.org/10.1016/j.jgar.2024.03.003
[259] Providing guidelines and education is not enough: an audit of gentamicin use at The Royal Melbourne Hospital. — https://doi.org/10.1111/j.1445-5994.2006.01002.x
[260] Intrathecal penetration of meropenem and vancomycin administered by continuous infusion in patients suffering from ventriculitis-a retrospective analysis. — https://doi.org/10.1007/s00701-018-3680-z
[263] Evaluation of Assays to Measure Aminoglycosides in Serum: Comparison of Accuracy and Precision Based on External Quality Assessment. — https://doi.org/10.1097/ftd.0000000000000752
[264] Measurement of Total and Free Cefiderocol Concentrations in Human Plasma by UHPLC-MS/MS: Application to Patients With Difficult-To-Treat Gram-Negative Bacterial Infections. — https://doi.org/10.1002/jssc.70237
[267] [Cost-effectiveness analysis of active TDM in elderly patients treated with aminoglycosides]. — https://doi.org/10.2515/therapie/2011058
[270] The impact of pharmacist-led education and prospective audit and feedback on antibiotic dose optimization within medical intensive care units in Thailand: a retrospective study. — https://doi.org/10.1080/20523211.2025.2467456
[273] Therapeutic vancomycin monitoring in children with hydrocephalus during treatment of shunt infections. — https://doi.org/10.1016/j.surneu.2003.11.014
[274] Elimination of glycopeptide antibiotics by cytokine hemoadsorption in patients with septic shock: A study of three cases. — https://doi.org/10.1177/0391398820917151
[287] Augmented renal clearance in the Intensive Care Unit: an illustrative case series. — https://doi.org/10.1016/j.ijantimicag.2010.02.013
[296] Adequate posology of antimicrobial therapy in the septic critically ill in continuous veno-venous hemofiltration: a single centre prospective observational study. — https://doi.org/10.1093/jac/dkaf089
[301] Interest of therapeutic drug monitoring of aminoglycosides administered by a monodose regimen. — https://doi.org/10.1016/j.nephro.2018.08.004
[308] Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics: An Applicability Study in Intensive Care Unit Patients. — https://doi.org/10.1097/ftd.0000000000000827
[312] Beta-Lactam Antibiotic Therapeutic Drug Monitoring in Critically Ill Patients: A Systematic Review and Meta-Analysis. — https://doi.org/10.1093/cid/ciac506
[313] Meropenem PK/PD Variability and Renal Function: "We Go Together". — https://doi.org/10.3390/pharmaceutics15092238
[321] Individualization of piperacillin dosage based on therapeutic drug monitoring with or without model-informed precision dosing: a scenario analysis. — https://doi.org/10.1093/jac/dkaf007
[324] Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: lessons from the DALI Study. — https://doi.org/10.1016/j.ijantimicag.2014.01.023
[325] Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring. — https://doi.org/10.3390/pharmacy7010020
[330] Monitoring Plasma Concentrations of Intravenously Administered Fosfomycin to Prevent Drug-Related Adverse Events: A Retrospective Observational Study. — https://doi.org/10.3390/antibiotics14060548
[331] Sampling time and indications appropriateness for therapeutically monitored drugs at a teaching university hospital in Oman. — https://doi.org/10.1016/j.jsps.2014.11.005
[332] Two-dimensional liquid chromatography measurement of meropenem concentration in synovial fluid of patients with periprosthetic joint infection. — https://doi.org/10.1002/bmc.5778
[333] Effects of biobanking conditions on six antibiotic substances in human serum assessed by a novel evaluation protocol. — https://doi.org/10.1515/cclm-2015-0325
[334] Considerable variation of trough β-lactam concentrations in older adults hospitalized with infection-a prospective observational study. — https://doi.org/10.1007/s10096-018-3194-x
[337] Optimising Meropenem and Piperacillin Dosing in Patients Undergoing Extracorporeal Membrane Oxygenation Without Renal Dysfunction (MEPIMEX). — https://doi.org/10.3390/antibiotics14090939
[338] Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial. — https://doi.org/10.1007/s00134-013-3187-2
[339] Population Pharmacokinetics of Vancomycin in Pregnant Women. — https://doi.org/10.3389/fphar.2022.873439
[345] Obesity in critically ill patients is associated with increased need of mechanical ventilation but not with mortality. — https://doi.org/10.1016/j.jiph.2015.12.003
[346] Evaluation of Antimicrobial Resistance in Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia. — https://doi.org/10.3390/medicina60060850
[347] Real-world experience of therapeutic drug monitoring and PK/PD achievement of ceftaroline administered by different infusion regimens in patients with confirmed infections caused by Gram-positive bacteria. — https://doi.org/10.1093/jac/dkad296
[348] Plasma Concentrations of Benzylpenicillin and Cloxacillin in Infective Endocarditis-With Special Reference to Delayed Hypersensitivity Reactions. — https://doi.org/10.3390/antibiotics14010056
[350] A Monocentric Retrospective Study of AUC/MIC Ratio of Vancomycin Associated with Clinical Outcomes and Nephrotoxicity in Patients with Enterococcal Infections. — https://doi.org/10.3390/pharmaceutics13091378
[353] Protein binding of β-lactam antibiotics in critically ill patients: can we successfully predict unbound concentrations? — https://doi.org/10.1128/aac.00951-13
[365] Stability of 10 Beta-Lactam Antibiotics in Human Plasma at Different Storage Conditions. — https://doi.org/10.1097/ftd.0000000000001100
[368] Improving Meropenem Quantification in a Compact SERS-Based Centrifugal Microfluidic Platform: Toward TDM of Antibiotics in ICU. — https://doi.org/10.1021/acs.analchem.4c06902
[371] Experience of Vancomycin Therapeutic Drug Monitoring in Two Multidisciplinary Hospitals in Latvia. — https://doi.org/10.3390/medicina58030370
[376] Pharmacokinetic changes of antibiotic, antiviral, antituberculosis and antifungal agents during extracorporeal membrane oxygenation in critically ill adult patients. — https://doi.org/10.1111/jcpt.12636
[381] Principles of antibacterial dosing in continuous renal replacement therapy. — https://doi.org/10.1159/000321488
[382] Hemoadsorption with CytoSorb and the early course of linezolid plasma concentration during septic shock. — https://doi.org/10.1007/s10047-021-01274-4
[383] [Antimicrobial Stewardship and Education, the Role of Pharmacists in the University Hospital]. — https://doi.org/10.1248/yakushi.21-00107-2
[384] Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study. — https://doi.org/10.1016/j.cmi.2017.01.005
[388] Vancomycin-Induced Acute Kidney Injury in Intensive Care Patients: A Target Trial Emulation Study Using Multicenter Routinely Collected Data. — https://doi.org/10.1002/pds.70205
[392] Thrice-weekly teicoplanin: an old drug for modern needs. Experience of its use as outpatient parenteral antibiotic therapy (OPAT) at infectious disease unit of Manzoni hospital (Lecco). — https://doi.org/10.1080/1120009x.2025.2575226
[394] Simultaneous quantification of cefepime, meropenem, ciprofloxacin, moxifloxacin, linezolid and piperacillin in human serum using an isotope-dilution HPLC-MS/MS method. — https://doi.org/10.1016/j.jpba.2018.01.031
[396] Real-Life Experience of Continuously Infused Ceftolozane/Tazobactam in Patients with Bronchiectasis and Multidrug-Resistant Infection in the Outpatient Setting. — https://doi.org/10.3390/antibiotics12071214
[397] Adequate plasma drug concentrations suggest that amoxicillin can be administered by continuous infusion using elastomeric pumps. — https://doi.org/10.1093/jac/dkx178
[402] An evaluation of risk factors to predict target concentration non-attainment in critically ill patients prior to empiric β-lactam therapy. — https://doi.org/10.1007/s10096-018-3357-9
[404] Applicability of vancomycin, meropenem, and linezolid in capillary microsamples vs. dried blood spots: A pilot study for microsampling in critically ill children. — https://doi.org/10.3389/fped.2022.1055200
[409] [Specific variability of teicoplanin protein binding in patients receiving continuous hemodiafiltration-comparison with hypoalbuminemia patients]. — https://doi.org/10.1248/yakushi.13-00002
[411] An international survey on aminoglycoside practices in critically ill patients: the AMINO III study. — https://doi.org/10.1186/s13613-021-00834-4
[416] Target attainment with continuous dosing of piperacillin/tazobactam in critical illness: a prospective observational study. — https://doi.org/10.1016/j.ijantimicag.2017.02.020
[422] Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. — https://doi.org/10.1007/s00431-022-04716-0
[423] Impact of carbapenem antibiotics on mycophenolate mofetil in hematopoietic stem cell transplant patients with interruption of the enterohepatic recycling: a retrospective study. — https://doi.org/10.21037/atm-22-6341
[424] Pharmacist-Driven Dosing Services and Pharmaceutical Care Increase Probability of Teicoplanin Target Concentration Attainment and Improve Clinical and Economic Outcomes in Non-Critically Ill Patients. — https://doi.org/10.1007/s40121-023-00812-2
[427] Cefepime neurotoxicity: thresholds and risk factors. A retrospective cohort study. — https://doi.org/10.1016/j.cmi.2019.06.028
[428] Continuous infusion of beta-lactam antibiotics in pediatric intensive care unit: A monocenter before/after implementation study. — https://doi.org/10.1016/j.accpm.2024.101354
[432] Intraperitoneally Administered Vancomycin Results in Suboptimal Serum and Peritoneal Effluent Drug Levels in Patients with PD-related Peritonitis. — https://doi.org/10.25259/ijn_59_2024
[433] Efficiency of dosing software using Bayesian forecasting in achieving target antibiotic exposures in critically ill patients, a prospective cohort study. — https://doi.org/10.1016/j.accpm.2023.101296
[443] Benefits of pharmacist intervention in the critical care patients with infectious diseases: A propensity score matching retrospective cohort study. — https://doi.org/10.1016/j.aucc.2022.12.011
[448] Beta-Lactam Antibiotic Exposure During Pediatric Extracorporeal Membrane Oxygenation: Retrospective Cohort Analysis of Drug Levels Using Standard Dosing, 2018-2020. — https://doi.org/10.1097/pcc.0000000000003605
[450] Preanalytical Stability of Piperacillin, Tazobactam, Meropenem, and Ceftazidime in Plasma and Whole Blood Using Liquid Chromatography-Tandem Mass Spectrometry. — https://doi.org/10.1097/ftd.0000000000000650
[451] Population Pharmacokinetic Modeling of Cefepime, Meropenem, and Piperacillin-Tazobactam in Patients With Cystic Fibrosis. — https://doi.org/10.1093/infdis/jiae451
[453] Pharmacokinetic and pharmacodynamic profiling of four antimicrobials against Acinetobacter baumannii infection. — https://doi.org/10.1016/j.micpath.2019.103809
[455] Too much of a good thing: a retrospective study of β-lactam concentration-toxicity relationships. — https://doi.org/10.1093/jac/dkx209
[457] Predictors for non-attainment of meropenem target concentrations when treating infections in critically ill patients. — https://doi.org/10.5414/cp204412
[458] Accuracy of a precision dosing software program for predicting antibiotic concentrations in critically ill patients. — https://doi.org/10.1093/jac/dkac392
[469] Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study. — https://doi.org/10.1186/s13613-023-01184-z
[472] Effectiveness of Pharmacokinetic/Pharmacodynamic-Guided Meropenem Treatment in Critically Ill Patients: A Comparative Cohort Study. — https://doi.org/10.1097/ftd.0000000000000826
[474] Pilot study of oral fluid and plasma meropenem and piperacillin concentrations in the intensive care unit. — https://doi.org/10.1016/j.cca.2021.09.005
[475] A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics. — https://doi.org/10.1186/s13054-015-0818-8
[479] Using Electronic Health Records for Personalized Dosing of Intravenous Vancomycin in Critically Ill Neonates: Model and Web-Based Interface Development Study. — https://doi.org/10.2196/29458
[480] Relationship between nephrotoxicity and area under the concentration-time curve of vancomycin in critically ill patients: a multicenter retrospective study. — https://doi.org/10.1128/spectrum.03739-23
[483] Neurological burden and outcomes of excessive β-lactam serum concentrations of critically ill septic patients: a prospective cohort study. — https://doi.org/10.1093/jac/dkad284
[491] Low attainment to PK/PD-targets for β-lactams in a multi-center study on the first 72 h of treatment in ICU patients. — https://doi.org/10.1038/s41598-022-25967-9
[498] Target Site Pharmacokinetics of Meropenem: Measurement in Human Explanted Lung Tissue by Bronchoalveolar Lavage, Microdialysis, and Homogenized Lung Tissue. — https://doi.org/10.1128/aac.01564-21
[503] Population Pharmacokinetics of Vancomycin in Critically Ill Adult Patients Receiving Extracorporeal Membrane Oxygenation (an ASAP ECMO Study). — https://doi.org/10.1128/aac.01377-21
[504] Population pharmacokinetics of vancomycin in critically ill patients receiving prolonged intermittent renal replacement therapy. — https://doi.org/10.1016/j.ijantimicag.2018.03.001
[508] Pharmacokinetics and Pharmacodynamics of Meropenem by Extended or Continuous Infusion in Low Body Weight Critically Ill Patients. — https://doi.org/10.3390/antibiotics10060666

Therapeutic Drug Monitoring (TDM) of Antibiotics: Scoping Review with ☸️SAIMSARA.

Infectious Diseases

Issue 7, Volume 1, 2026

Monitoring can change the dose

Standard ICU dosing often misses

Overexposure is also a safety issue

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