Y chromosome loss emerges in this paper not as a passive marker of ageing, but as a potentially central male-specific biological signal linked to cardiovascular death, cancer progression, neurodegeneration, and immune dysfunction across a massive evidence base. The full paper is worth reading because it shows where this signal is strongest, how consistent it is across 1,048 original studies, and why LOY may become both a prognostic biomarker and a future therapeutic target.
Doc: Y_CHROMOSOME_LOSS_SS • v2026-02-28 • Editorial check 2026-03-15