AI-Native Scoping Reviews & Evidence Mapping

Diabetic foot is not just a wound problem but a high-stakes collision of neuropathy, ischemia, infection, and delayed care, with a median major amputation rate of 10.3% across the mapped evidence. This review shows where the strongest signals truly are: why multidisciplinary care can cut major amputations by up to 80%, which risk factors matter most, and which emerging diagnostics and regenerative therapies may actually change outcomes.

This review shows where thrombolysis in DVT truly helps and where it does not: the clearest signal is in selected iliofemoral disease, where modern catheter-based clot removal may improve patency and reduce post-thrombotic syndrome, but only at the cost of real bleeding risk. Read the full paper to see which techniques look most promising, which patients benefit most, and where the evidence still breaks down.

Deep vein thrombosis is not one disease trigger, but a convergence of risk: genes, cancer, surgery, catheters, hormones, infection, inflammation, and immobility can all push the body toward clot formation. This review maps where the strongest danger signals appear — from COVID-19 and oral contraceptives to cancer care and inherited thrombophilia — and shows why modern DVT prevention must be personalized rather than one-size-fits-all.

This review shows that DVT is not just a problem of stasis — it is a biologically active inflammatory process driven by endothelial injury, platelet–leukocyte crosstalk, and NET-mediated immunothrombosis. Read the full paper to see which mechanisms are strongest, which patient phenotypes carry the clearest signals, and which emerging biomarkers and targets could reshape risk stratification and therapy.

This paper shows that DCB is not just a technical upgrade over POBA, but a consistently stronger strategy for restenosis-prone vascular disease, with better patency and fewer repeat interventions across coronary ISR, femoropopliteal lesions, BTK disease, and dialysis access. The full paper is worth reading because it reveals where that advantage is most convincing, where technique and vessel preparation change the outcome, and how much of DCB’s real-world value lies in selecting the right lesion, not just the device.

The paper tackles one of endovascular medicine’s most controversial questions: whether DCBs truly carry a late mortality risk. Mapping 170 original studies, it shows why the feared signal largely fades in broader evidence, where comorbidity and indication matter more than the device itself — and reveals the few settings where uncertainty still remains.

This paper shows that daylight saving time is not a harmless calendar ritual: the clock changes align with measurable spikes in mortality, suicide, cardiovascular events, sleep loss, and road danger, with the spring and autumn transitions carrying distinct risks. Read the full paper to see where the strongest signals emerge, which outcomes remain inconsistent, and why the evidence increasingly points toward ending biannual clock changes rather than treating them as a neutral social habit.

CLTI/CLI is not always the end of the road: this review maps the emerging alternatives that may help selected “no-option” patients avoid or delay amputation, from cell and gene therapy to venous arterialization, retrograde access, and adjunctive pharmacology. The full paper shows where the evidence is clinically promising, where it remains experimental, and which strategies may realistically enter limb-salvage practice next.

Some of the most dangerous cracked teeth are the ones that still look normal. This review shows why early recognition and timely cuspal protection matter — before a subtle crack becomes a restorative and biologic disaster.

This review maps 260 original studies and 80,624 participants into a practical evidence layer on where coil embolization helps in aortic aneurysm repair — especially type II endoleak prevention, sac behavior, and staged spinal-cord-protection strategies. It also shows the trade-offs that matter clinically: recurrent endoleaks, buttock claudication, radiation exposure, infection risk, coil migration, and when coils, plugs, Onyx, NBCA, or anatomy-driven alternatives may be preferable.