AI-Native Scoping Reviews & Evidence Mapping

To synthesize current evidence regarding the clinical efficacy, biological mechanisms, and patient-centered outcomes of larval therapy in the management of acute and chronic wounds across human and animal models. The review utilises 94 original studies with 12244 total participants (topic deduplicated ΣN). Across the mapped evidence, larval therapy emerged most consistently as a rapid biological debridement strategy, with reported signals including a 92.3% wound-healing rate in post-revascularization ischemic wounds versus 18.2% with vacuum-assisted closure at one month, median free-range debr…

IVUS is not simply “better imaging” — this review shows where intravascular ultrasound changes real outcomes: complex coronary PCI, long lesions, diabetic ACS, femoropopliteal intervention, and iliofemoral venous disease. The full paper is worth reading because it maps when IVUS should be selectively adopted, when routine use adds little, and where AI-driven and hybrid intravascular imaging may define the next generation of endovascular precision.

This paper shows that the ischemic penumbra is not just a fading border around stroke core, but a dynamic and biologically active therapeutic target whose fate depends on collaterals, metabolism, BBB integrity, and how fast true reperfusion is achieved. The full read is worth it because it separates the real clinical signal from the hype—showing where tissue-based stroke decisions already work, where imaging and software still disagree, and which next-generation strategies may actually preserve salvageable brain.

The aim of this review is to synthesize the current scientific literature regarding the biological activities, clinical efficacy, and safety profile of guarana across human, animal, and in vitro models. The review utilises 167 original studies with 251199 total participants (topic deduplicated ΣN). The evidence map suggests that guarana has its clearest human signals in acute cognitive performance and metabolic regulation, alongside notable safety concerns at higher stimulant exposures. In particular, guarana-containing interventions were associated with body fat reductions of 5.53% at 4 weeks…

This paper shows that Gritti-Stokes amputation may offer more than limb removal alone: in selected patients it appears to preserve a more stable, functional stump with surprisingly strong links to prosthetic fitting, mobility, and even longer-term survival. The full paper is worth reading because it clarifies where this old technique still has real modern value, which patients may benefit most, and why its outcomes may compare more favorably than many assume.

This paper shows that GLP-1 receptor agonists are no longer just metabolic drugs: across a broad evidence base, they emerge as cardioprotective therapies linked to lower MACE, stroke, mortality, and even limb events, with signals extending from atherosclerosis to heart failure and vascular biology. The full paper is worth reading because it distinguishes where the cardiovascular benefit is strongest, where arrhythmic and perioperative uncertainties remain, and why underuse in real-world practice may be limiting their true impact.

This paper shows that the future of scientific publishing will not be defined by AI alone, but by whether publishing can become more transparent, machine-readable, open, and resistant to predatory and low-signal science at the same time. The full read is worth it because it maps where this transition is already happening, where it is failing, and which concrete changes in publishing, peer review, and research evaluation are most likely to matter next.

Fitness trackers are moving from wellness gadgets to clinical monitoring tools, but their value depends on accuracy, adherence, and workflow integration. The full paper is worth reading because it separates useful clinical signals — step count, heart rate, recovery, prognosis — from the hype around standalone digital health.

FEVAR has matured into a first-line endovascular strategy for anatomically suitable complex aortic aneurysms, delivering high technical success and low early mortality — but its real cost is lifelong surveillance and a substantial late reintervention burden. This review maps where FEVAR clearly outperforms open repair, where durability remains uncertain, and how fusion imaging, CO₂ angiography, bridging-stent choice, spinal-cord protection, and patient selection shape modern outcomes.

This paper shows that fasting diets are not just weight-loss strategies, but biologically active interventions that may improve macrovascular health through better arterial function, lower vascular inflammation, and ketone-linked protective mechanisms. It is worth reading because it also reveals the key clinical tension behind the field: vascular benefits are promising, but microvascular responses may diverge, making patient selection and endpoint interpretation crucial.

Endovascular aneurysm repair (EVAR) wins early, especially in ruptured and high-risk Abdominal aortic aneurysm — but open repair still wins durability in younger, fitter patients. This review maps where the trade-off truly lies: early survival and faster recovery versus lifelong surveillance, reintervention burden, renal decline, endoleaks, and uncertain late risks.

EVAR saves lives early, especially in ruptured abdominal aortic aneurysm, but it is not a “fit-and-forget” repair. This review maps where EVAR is strongest, where open surgery remains more durable, and why anatomy, frailty, sex-specific morphology, endoleaks, and lifelong surveillance decide the real long-term outcome.