AI-Native Scoping Reviews & Evidence Mapping

High-intensity focused ultrasound is emerging as a versatile precision platform for noninvasive tissue ablation, with clinical value spanning cancer, uterine disease, prostate therapy, neurological disorders, vascular applications, and more. The full review reveals where HIFU delivers the strongest benefits, which anatomical and technical factors determine success, and where serious complications, residual disease, and evidence gaps still limit routine use.

Fast food is more than a convenient meal—it is a recurring marker of poorer diet quality, obesity, cardiometabolic risk, mental-health symptoms, sleep disruption, and environmental exposure across diverse populations. Drawing on 735 references and 1,469 original studies, the full review reveals where the evidence is strongest, which risks are most consistent, and which interventions may offer the greatest real-world impact.

Climacteric symptoms extend far beyond hot flushes, affecting sleep, mood, cognition, sexual health, work ability, and overall quality of life across the menopausal transition. The full review reveals which hormonal, non-hormonal, botanical, behavioral, and device-based treatments show the most meaningful benefits—and how treatment should be matched to each woman’s symptoms, risks, and clinical context.

Single-parent family status is not a deterministic risk factor, but it repeatedly signals where children and caregivers may face greater pressure across mental health, chronic illness management, healthcare access, socioeconomic disadvantage, and health-risk behaviors. The full review reveals which risks are most consistent, which family and social supports can buffer them, and where interventions should be tailored rather than generalized.

Endovascular atherectomy delivers high technical success across peripheral, coronary, and selected non-atherosclerotic vascular conditions, yet its long-term clinical advantage remains highly dependent on anatomy, device, and treatment strategy. The full review reveals where atherectomy adds real value, where risks and reinterventions rise, and which applications remain unsupported.

Medical deepfakes can already fool radiologists and advanced AI systems, while detection models often report near-perfect accuracy only in controlled datasets. This review reveals where the real risks lie, how synthetic medical data may also benefit healthcare, and what must change before clinical systems can be trusted.

Interatrial shunts can either unload the failing left atrium or drive stroke, hypoxemia, and right-heart deterioration—depending on flow direction and the underlying cardiac phenotype. Built from 218 references, 502 original studies, and 77,138 observations, this review reveals which patients may benefit from shunt creation, who may be harmed, and when closure becomes clinically decisive.