AI-Native Scoping Reviews & Evidence Mapping

Fractional flow reserve is no longer just a coronary pressure number—it is a decision framework that reshapes revascularization, deferral, imaging, plaque assessment, and vascular risk stratification across clinical settings. This full read maps 3,488 original studies, 615 key references, and more than 42.4 million observations to show where FFR is reliable, where it fails, and why physiology must increasingly be combined with plaque and microvascular context.

Gender-affirming hormone therapy is not a single cardiovascular exposure: testosterone, estrogen route, anti-androgen choice, age, comorbidity, and monitoring all shift the risk picture. This full read maps 319 original studies, 114 key references, and more than 15.7 million observations to clarify where GAHT appears safer, where vascular risk signals emerge, and what clinicians should watch before relying on generic sex-based risk calculators.

This review shows that diving is not simply dangerous or beneficial, but a health-sensitive exposure where cardiac disease, obesity, barotrauma, decompression illness, and poor emergency planning define much of the risk. The full read maps 139 references across 273 original studies and over 105 million observations, clarifying when scuba, breath-hold, occupational, and therapeutic diving may be safe, harmful, or clinically useful.

This review shows that ramipril and candesartan are not simply interchangeable RAAS drugs: blood-pressure control is broadly comparable, but the evidence separates them by exercise BP response, tolerability, diastolic function, anti-fibrotic signals, and perioperative fibrinolytic effects. The full read maps 37 references across 33 original studies and 399,243 observations, clarifying where candesartan, ramipril, or single-pill combinations may offer the more rational clinical choice.

Pornography is not a single-risk exposure but a complex behavioral ecosystem where most users report neutral or positive effects, while a clinically important minority develop problematic use linked to mental distress, relationship conflict, risky sexual behavior, and aggression-related outcomes. The full read maps 318 references across 1,287 original studies, separating frequency from problematic use and showing where pornography literacy, couple context, moral incongruence, and targeted screening may actually matter.

CO2 angiography is not simply an “iodine-free alternative,” but a selective kidney-sparing imaging strategy with strongest value in CKD, contrast allergy, dialysis access, peripheral interventions, renal procedures, and EVAR. The full read clarifies where CO2 truly helps, where image quality fails—especially below the knee—and which rare but severe complications demand careful technique and patient selection.

This review shows that intravascular lithotripsy is no longer a niche calcium tool, but an expanding platform across coronary PCI, peripheral interventions, TAVR access, stent failure, and complex off-label vascular anatomy. The full read clarifies where IVL is best supported, where evidence is still case-based, and how procedural success, complications, imaging guidance, and long-term durability should shape real clinical use.

This review reframes pelvic venous congestion as a hemodynamic disorder of reflux, distribution, and venous outflow obstruction, not simply enlarged pelvic veins. The full read shows where embolization, stenting, combined treatment, and broader symptom recognition can change diagnosis and management in patients often missed by standard pelvic-pain pathways.

This review shows that sclerotherapy—especially ultrasound-guided foam—is an effective, low-burden option for varicose veins, but durability is weaker than thermal ablation or surgery in truncal reflux. The full paper defines where it works best, when adjunctive use is smarter, and which safety risks deserve attention.

RFA is a durable, minimally invasive option for varicose veins, but device choice and aftercare should be individualized. This SAIMSARA review maps 130 references and 146 original studies to clarify closure rates, recurrence, thrombosis risk, compression use, and comparisons with EVLA, cyanoacrylate, MOCA, foam, and surgery.